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  1. [13N]Ammonia is a cyclotron produced myocardial perfusion imaging agent. With the development of high-yielding [13N]ammonia cyclotron targets using a solution of 5 mM ethanol in water, there was a need to develop...

    Authors: Daniel L. Yokell, Peter A. Rice, Ramesh Neelamegam and Georges El Fakhri
    Citation: EJNMMI Radiopharmacy and Chemistry 2020 5:11
  2. Lymph node dissection is a therapeutic option for prostate cancer patients with a high risk of- or proven lymph node metastases. Radioguided surgery after intravenous injection of [99mTc]Tc-PSMA could improve the...

    Authors: Else A. Aalbersberg, Lotte van Andel, Martine M. Geluk-Jonker, Jos H. Beijnen, Marcel P. M. Stokkel and Jeroen J. M. A. Hendrikx
    Citation: EJNMMI Radiopharmacy and Chemistry 2020 5:10
  3. The radiochemical purity (RCP) of technetium-99m labelled radiopharmaceuticals (RP) is important to ensure optimal scintigraphic image quality. In low-income settings, it may not be possible to use compendial ...

    Authors: F. P. Ekoume, H. H. Boersma, F. Dong à Zok and S. M. Rubow
    Citation: EJNMMI Radiopharmacy and Chemistry 2020 5:9
  4. PentixaFor is a promising radiopharmaceutical for positron emission tomography in the detection of different tumor entities and other diseases. Until now, the synthesis of [68Ga]Ga-PentixaFor was reported for the...

    Authors: Sarah Spreckelmeyer, Oliver Schulze and Winfried Brenner
    Citation: EJNMMI Radiopharmacy and Chemistry 2020 5:8
  5. To fulfil good manufacturing requirements, analytical methods for the analysis of pharmaceuticals for human and vetinary use must be validated. The International Conference on Harmonization of Technical Requir...

    Authors: Nic Gillings, Sergio Todde, Martin Behe, Clemens Decristoforo, Philip Elsinga, Valentina Ferrari, Olaug Hjelstuen, Petra Kolenc Peitl, Jacek Koziorowski, Peter Laverman, Thomas L. Mindt, Meltem Ocak and Marianne Patt
    Citation: EJNMMI Radiopharmacy and Chemistry 2020 5:7
  6. The IsoDAR collaboration is developing a high-current cyclotron for a neutrino search experiment. Designed to deliver 10 mA of 60 MeV protons, the current and power of this cyclotron far exceed those of existi...

    Authors: Loyd H. Waites, Jose R. Alonso, Roger Barlow and Janet M. Conrad
    Citation: EJNMMI Radiopharmacy and Chemistry 2020 5:6
  7. Here we report on the comprehensive quality control of a 4.04 GBq (109 mCi) generator supplied by itG (Munich, Germany), and used for routine production of [68Ga]Ga-PSMA-11 for clinical imaging. The performance o...

    Authors: Nicole N. Waterhouse, Alejandro Amor-Coarasa, Anastasia Nikolopoulou and John W. Babich
    Citation: EJNMMI Radiopharmacy and Chemistry 2020 5:5
  8. Gallium-68 labeled synthetic somatostatin analogs for PET/CT imaging are the current gold standard for somatostatin receptor imaging in neuroendocrine tumor patients. Despite good imaging properties, their use...

    Authors: Térence Tshibangu, Christopher Cawthorne, Kim Serdons, Elin Pauwels, Willy Gsell, Guy Bormans, Christophe M. Deroose and Frederik Cleeren
    Citation: EJNMMI Radiopharmacy and Chemistry 2020 5:4
  9. Targeted therapy of HER2 positive breast cancer has led to clinical success in some cases with primary and secondary resistance being major obstacles. Due to the substantial involvement of mTOR kinase in cell ...

    Authors: Christian W. Wichmann, Yit Wooi Goh, Adam C. Parslow, Angela Rigopoulos, Nancy Guo, Andrew M. Scott, Uwe Ackermann and Jonathan M. White
    Citation: EJNMMI Radiopharmacy and Chemistry 2020 5:3
  10. Over the last several years, the use of radiometals has gained increasing relevance in supporting the continuous development of new, complementary and more specific biological targeting agents. Radiopharmaceut...

    Authors: Sergio J. C. do Carmo, Peter J. H. Scott and Francisco Alves
    Citation: EJNMMI Radiopharmacy and Chemistry 2020 5:2
  11. Conventional scale production of small batches of PET tracers (e.g. for preclinical imaging) is an inefficient use of resources. Using O-(2-[18F]fluoroethyl)-L-tyrosine ([18F]FET), we demonstrate that simple micr...

    Authors: Ksenia Lisova, Bao Ying Chen, Jia Wang, Kelly Mun-Ming Fong, Peter M. Clark and R. Michael van Dam
    Citation: EJNMMI Radiopharmacy and Chemistry 2019 5:1
  12. [11C]Metoclopramide is a new radiotracer for investigating the activity of P-glycoprotein at the blood-brain barrier. A highly stable and reproducible radiosynthesis is a prerequisite for clinical studies applyin...

    Authors: Verena Pichler, Marius Ozenil, Karsten Bamminger, Chrysoula Vraka, Marcus Hacker, Oliver Langer and Wolfgang Wadsak
    Citation: EJNMMI Radiopharmacy and Chemistry 2019 4:31
  13. [11C]UCB-J is a tracer developed for PET (positron emission tomography) that has high affinity towards synaptic vesicle glycoprotein 2A (SV2A), a protein believed to participate in the regulation of neurotransmit...

    Authors: Johanna Rokka, Eva Schlein and Jonas Eriksson
    Citation: EJNMMI Radiopharmacy and Chemistry 2019 4:30
  14. Immunotherapy with checkpoint inhibitors demonstrates impressive improvements in the treatment of several types of cancer. Unfortunately, not all patients respond to therapy while severe immune-related adverse...

    Authors: Peter Wierstra, Gerwin Sandker, Erik Aarntzen, Martin Gotthardt, Gosse Adema, Johan Bussink, René Raavé and Sandra Heskamp
    Citation: EJNMMI Radiopharmacy and Chemistry 2019 4:29
  15. Copper-mediated radiofluorination is a straightforward method to produce a variety of [18F]fluoroarenes and [18F]fluoroheteroarenes. To minimize the number of steps in the production of 18F-labelled radiopharmace...

    Authors: Salla Orvokki Lahdenpohja, Noora Annika Rajala, Johan Rajander and Anna Kaarina Kirjavainen
    Citation: EJNMMI Radiopharmacy and Chemistry 2019 4:28
  16. Auger electrons (AEs) are very low energy electrons that are emitted by radionuclides that decay by electron capture (e.g. 111In, 67Ga, 99mTc, 195mPt, 125I and 123I). This energy is deposited over nanometre-micro...

    Authors: Anthony Ku, Valerie J. Facca, Zhongli Cai and Raymond M. Reilly
    Citation: EJNMMI Radiopharmacy and Chemistry 2019 4:27
  17. Recent studies showed that ethanol in the reaction mixture improves radiolabelling with trivalent radiometals in terms of precursor amount, reaction time, reaction temperature and radiolysis. With regard to cl...

    Authors: Michael Meisenheimer, Stefan Kürpig, Markus Essler and Elisabeth Eppard
    Citation: EJNMMI Radiopharmacy and Chemistry 2019 4:26
  18. [11C]Carbon monoxide is an appealing synthon for introducing carbon-11 at a carbonyl position (C=O) in a wide variety of chemotypes (e.g., amides, ketones, acids, esters, and ureas). The prevalence of the carbony...

    Authors: Carlotta Taddei and Victor W. Pike
    Citation: EJNMMI Radiopharmacy and Chemistry 2019 4:25
  19. PET radiopharmaceutical development and the implementation of a production method on a synthesis module is a complex and time-intensive task since new synthesis methods must be adapted to the confines of the s...

    Authors: Christopher Frank, Georg Winter, Fredrik Rensei, Victor Samper, Allen F. Brooks, Brian G. Hockley, Bradford D. Henderson, Christian Rensch and Peter J. H. Scott
    Citation: EJNMMI Radiopharmacy and Chemistry 2019 4:24
  20. Gallium-68 ([68Ga]Ga) labelled radiopharmaceuticals have become a valuable tool in clinical practice using Positron Emission Tomography (PET). These agents are typically produced on-site owing to the short half-l...

    Authors: Mohammad B. Haskali, Peter D. Roselt, David Binns, Amit Hetsron, Stan Poniger, Craig A. Hutton and Rodney J. Hicks
    Citation: EJNMMI Radiopharmacy and Chemistry 2019 4:23
  21. The EU directive 2001/83 describes the community code for medicinal products for human use including radiopharmaceuticals. In its current definition, also radionuclide precursors, such as fluorine-18, need to ...

    Authors: Oliver Neels, Marianne Patt and Clemens Decristoforo
    Citation: EJNMMI Radiopharmacy and Chemistry 2019 4:22
  22. Actinium-225 (225Ac, t1/2 = 9.9 d) is a promising candidate radionuclide for use in targeted alpha therapy (TAT), though the currently limited global supply has hindered the development of a suitable Ac-chelating...

    Authors: Caterina F. Ramogida, Andrew K. H. Robertson, Una Jermilova, Chengcheng Zhang, Hua Yang, Peter Kunz, Jens Lassen, Ivica Bratanovic, Victoria Brown, Lily Southcott, Cristina Rodríguez-Rodríguez, Valery Radchenko, François Bénard, Chris Orvig and Paul Schaffer
    Citation: EJNMMI Radiopharmacy and Chemistry 2019 4:21
  23. Dopamine receptors are involved in pathophysiology of neuropsychiatric diseases, including Huntington’s disease (HD). PET imaging of dopamine D2 receptors (D2R) in HD patients has demonstrated 40% decrease in ...

    Authors: Tuulia Huhtala, Pekka Poutiainen, Jussi Rytkönen, Kimmo Lehtimäki, Teija Parkkari, Iiris Kasanen, Anu J. Airaksinen, Teija Koivula, Patrick Sweeney, Outi Kontkanen, John Wityak, Celia Dominiquez and Larry C. Park
    Citation: EJNMMI Radiopharmacy and Chemistry 2019 4:20
  24. Over the years, a broad spectrum of applications of the radionuclide holmium-166 as a medical isotope has been established. The isotope holmium-166 is attractive as it emits high-energy beta radiation which ca...

    Authors: Nienke J. M. Klaassen, Mark J. Arntz, Alexandra Gil Arranja, Joey Roosen and J. Frank W. Nijsen
    Citation: EJNMMI Radiopharmacy and Chemistry 2019 4:19
  25. The term of neurodegenerative diseases covers a heterogeneous group of disorders that are distinguished by progressive degeneration of the structure and function of the nervous system such as dementias, moveme...

    Authors: Solveig Tiepolt, Marianne Patt, Gayane Aghakhanyan, Philipp M. Meyer, Swen Hesse, Henryk Barthel and Osama Sabri
    Citation: EJNMMI Radiopharmacy and Chemistry 2019 4:17
  26. Tumors form a complex environment consisting of a variety of non-malignant cells. Especially cancer-associated fibroblasts have been shown to have an important role for different aspects of malignant tumors su...

    Authors: Thomas Lindner, Anastasia Loktev, Frederik Giesel, Clemens Kratochwil, Annette Altmann and Uwe Haberkorn
    Citation: EJNMMI Radiopharmacy and Chemistry 2019 4:16
  27. Molecular imaging of immune cells might be a potential tool for response prediction, treatment evaluation and patient selection in inflammatory diseases as well as oncology. Targeting interleukin-2 (IL2) recep...

    Authors: Elly L. van der Veen, Inês F. Antunes, Petra Maarsingh, Janet Hessels-Scheper, Rolf Zijlma, Hendrikus H. Boersma, Annelies Jorritsma-Smit, Geke A. P. Hospers, Elisabeth G. E. de Vries, Marjolijn N. Lub-de Hooge and Erik F. J. de Vries
    Citation: EJNMMI Radiopharmacy and Chemistry 2019 4:15
  28. The β-amyloid radiotracer [11C] PiB is extensively used for the Positron Emission Tomography (PET) diagnosis of Alzheimer’s Disease and related dementias. For clinical use, [11C] PiB is produced using the 11C-met...

    Authors: Pablo Buccino, Eduardo Savio and Williams Porcal
    Citation: EJNMMI Radiopharmacy and Chemistry 2019 4:14
  29. In this work, a lutetium-177 (177Lu) production method based on the separation of nuclear isomers, 177mLu & 177Lu, is reported. The 177mLu-177Lu separation is performed by combining the use of DOTA & DOTA-labelle...

    Authors: Rupali Bhardwaj, Hubert Th. Wolterbeek, Antonia G. Denkova and Pablo Serra-Crespo
    Citation: EJNMMI Radiopharmacy and Chemistry 2019 4:13
  30. 161Tb is an interesting radionuclide for cancer treatment, showing similar decay characteristics and chemical behavior to clinically-employed 177Lu. The therapeutic effect of 161Tb, however, may be enhanced due t...

    Authors: Nadezda Gracheva, Cristina Müller, Zeynep Talip, Stephan Heinitz, Ulli Köster, Jan Rijn Zeevaart, Alexander Vögele, Roger Schibli and Nicholas P. van der Meulen
    Citation: EJNMMI Radiopharmacy and Chemistry 2019 4:12
  31. Many nuclear medicine departments have equipped themselves with automated dispensing systems (ADS) for PET radiopharmaceuticals, in both the operators’ and the patients’ interests. Whether partially or fully a...

    Authors: Tristan Martin, Anaïs Moyon, Cyril Fersing, Evan Terrier, Aude Gouillet, Fabienne Giraud, Benjamin Guillet and Philippe Garrigue
    Citation: EJNMMI Radiopharmacy and Chemistry 2019 4:11
  32. New regulatory guidance documents from the United States Food and Drug Administration (FDA) and the European Medicines Agency (EMA) have recently been finalized or are in draft format outlining new pathways fo...

    Authors: Sally W. Schwarz and Clemens Decristoforo
    Citation: EJNMMI Radiopharmacy and Chemistry 2019 4:10
  33. Radiolabeled exendin-4 (Ex4) derivatives are used to target the glucagon-like peptide-1 receptor (GLP-1R) for the clinical diagnosis of insulinomas, a rare type of neuroendocrine tumor. Gallium-68 is an ideal ...

    Authors: Simon A. M. Kaeppeli, Roger Schibli, Thomas L. Mindt and Martin Behe
    Citation: EJNMMI Radiopharmacy and Chemistry 2019 4:9
  34. Brain PET imaging with different tracers is mainly clinically used in the field of neurodegenerative diseases and brain tumors. In recent years, the potential usefulness of PET has also gained attention in the...

    Authors: Matteo Bauckneht, Selene Capitanio, Stefano Raffa, Luca Roccatagliata, Matteo Pardini, Caterina Lapucci, Cecilia Marini, Gianmario Sambuceti, Matilde Inglese, Paolo Gallo, Diego Cecchin, Flavio Nobili and Silvia Morbelli
    Citation: EJNMMI Radiopharmacy and Chemistry 2019 4:6
  35. L-Glutamine (L-Gln) is the most abundant amino acid present in the human body and is involved in numerous metabolic pathways. Glutaminolysis is the metabolic process deployed by many aggressive cancers such as...

    Authors: Prashanth K. Padakanti, Shihong Li, Alexander Schmitz, David Mankoff, Robert H. Mach and Hsiaoju S. Lee
    Citation: EJNMMI Radiopharmacy and Chemistry 2019 4:5
  36. Neuropeptide Y (NPY) has been implicated in a wide variety of physiological processes, including feeding, learning, memory, emotion, cardiovascular homeostasis, hormone secretion, and circadian rhythms. NPY Yl...

    Authors: Kazunori Kawamura, Wakana Mori, Masayuki Fujinaga, Tomoteru Yamasaki, Yiding Zhang, Hidekatsu Wakizaka, Akiko Hatori, Lin Xie, Katsushi Kumata, Takayuki Ohkubo, Yusuke Kurihara, Masanao Ogawa, Nobuki Nengaki and Ming-Rong Zhang
    Citation: EJNMMI Radiopharmacy and Chemistry 2019 4:4
  37. Clinically applied radiopharmaceuticals have to meet quality release criteria like a high radiochemical yield and radiochemical purity. Many radiopharmaceuticals do not have marketing authorization and have no...

    Authors: Erik de Blois, Rory M. S. de Zanger, Ho Sze Chan, Mark Konijnenberg and Wouter A. P. Breeman
    Citation: EJNMMI Radiopharmacy and Chemistry 2019 4:3
  38. The histological evaluation of estrogen receptor (ER) and progesterone receptor (PR) expression in breast cancer lesions from biopsy tissue can stratify patients to receive endocrine therapy. Furthermore, PR e...

    Authors: Louis Allott, Cecilia Miranda, Angela Hayes, Florence Raynaud, Christopher Cawthorne and Graham Smith
    Citation: EJNMMI Radiopharmacy and Chemistry 2019 4:1
  39. [11C]Methionine ([11C]MET) acts as an oncological radiopharmaceutical for measuring increased protein synthesis in brain tumours while having low uptake in normal brain an. In several Latin American countries, th...

    Authors: Javier Giglio, Gabriela Rosas, Martín Basso, Andrea Boné, Eduardo Savio and Henry Engler
    Citation: EJNMMI Radiopharmacy and Chemistry 2018 3:15
  40. The free-fatty acid receptor-1 (FFA-1) is expressed by β-cells and is a promising target for molecular imaging of functional β-cell mass. Recently, the ((3-[18F]fluoropropyl)sulfonyl)propoxy-derivative of the hig...

    Authors: Mark H. Dornan, Daniil Petrenyov, José-Mathieu Simard, Antonio Aliaga, Guoming Xiong, Julien Ghislain, Barry Bedell, Vincent Poitout and Jean N. DaSilva
    Citation: EJNMMI Radiopharmacy and Chemistry 2018 3:14
  41. The metadata in the HTML format of these original articles (Eppard et al., 2017; Decristoforo & Patt, 2017; Domnanich et al., 2017; Chan et al., 2017; Jovalekic et al., 2017; Zhang & Villalobos, 2017; Meckel e...

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    Citation: EJNMMI Radiopharmacy and Chemistry 2018 3:13

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  42. We recently upgraded our [18F]fludeoxyglucose (FDG) production capabilities with the goal of futureproofing our FDG clinical supply, expanding the number of batches of FDG we can manufacture each day, and improvi...

    Authors: Alexandra R Sowa, Isaac M Jackson, Timothy J Desmond, Jeremiah Alicea, Anthony J Mufarreh, Jonathan M Pham, Jenelle Stauff, Wade P Winton, Maria V Fawaz, Bradford D Henderson, Brian G Hockley, Virginia E Rogers, Robert A Koeppe and Peter J H Scott
    Citation: EJNMMI Radiopharmacy and Chemistry 2018 3:12
  43. Several P-glycoprotein (P-gp) substrate tracers are available to assess P-gp function in vivo, but attempts to develop a tracer for measuring expression levels of P-gp have not been successful. Recently, (Z)-2...

    Authors: Joost Verbeek, Jonas Eriksson, Stina Syvänen, Marc Huisman, Robert C. Schuit, Carla F. M. Molthoff, Rob A. Voskuyl, Elizabeth C. de Lange, Adriaan A. Lammertsma and Albert D. Windhorst
    Citation: EJNMMI Radiopharmacy and Chemistry 2018 3:11
  44. To study MMP activity in vivo in disease, several radiolabeled MMP inhibitors functioning as radiotracers have been evaluated by means of SPECT and PET. Unfortunately, most of them suffer from metabolic instab...

    Authors: Verena Hugenberg, Malte Behrends, Stefan Wagner, Sven Hermann, Michael Schäfers, Hartmuth C. Kolb, Katrin Szardenings, Joseph C. Walsh, Luis F. Gomez, Klaus Kopka and Günter Haufe
    Citation: EJNMMI Radiopharmacy and Chemistry 2018 3:10
  45. Targeted radionuclide therapy is a highly efficient but still underused treatment modality for various types of cancers that uses so far mainly readily available β-emitting radionuclides. By using α-particle e...

    Authors: Uwe Holzwarth, Isaac Ojea Jimenez and Luigi Calzolai
    Citation: EJNMMI Radiopharmacy and Chemistry 2018 3:9
  46. [11C]erlotinib has been proposed as a PET tracer to visualize the mutational status of the epidermal growth factor receptor (EGFR) in cancer patients. For clinical use, a stable, reproducible and high-yielding ra...

    Authors: Cécile Philippe, Severin Mairinger, Verena Pichler, Johann Stanek, Lukas Nics, Markus Mitterhauser, Marcus Hacker, Thomas Wanek, Oliver Langer and Wolfgang Wadsak
    Citation: EJNMMI Radiopharmacy and Chemistry 2018 3:8

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