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EJNMMI Radiopharmacy and Chemistry
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  1. 64Cu is one of the few radioisotopes that can be used for both imaging and therapy, enabling theranostics with identical chemical composition. Development of stable chelators is essential to harness the potentia....

    Authors: Hua Yang, Feng Gao, Brooke McNeil, Chengcheng Zhang, Zheliang Yuan, Stefan Zeisler, Joel Kumlin, Jutta Zeisler, François Bénard, Caterina Ramogida and Paul Schaffer
    Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:3
    Content type: Research article Published on:

  2. The purpose of this work was to design, validate and implement a media-fill test combined with fluorescein (MFT-F) for the specific qualification and training of radiopharmacy operators, in accordance with Uni...

    Authors: Cyril Fersing, Emmanuel Deshayes, Sarah Langlet, Laurence Calas, Vincent Lisowski and Pierre Olivier Kotzki
    Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:2
    Content type: Guideline article Published on:

  3. With increasing clinical demand for gallium-68, commercial germanium-68/gallium-68 ([68Ge]Ge/[68Ga]Ga) generators are incapable of supplying sufficient amounts of the short-lived daughter isotope. In this study, ...

    Authors: Helge Thisgaard, Joel Kumlin, Niels Langkjær, Jansen Chua, Brian Hook, Mikael Jensen, Amir Kassaian, Stefan Zeisler, Sogol Borjian, Michael Cross, Paul Schaffer and Johan Hygum Dam
    Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:1
    Content type: Research article Published on:

  4. [68Ga]Ga-FAPI-46 is a promising radiopharmaceutical for in vivo detection of the fibroblast activation protein by positron emission tomography. Until now, the synthesis of [68Ga]Ga-FAPI-46 has been only performed...

    Authors: Sarah Spreckelmeyer, Matthias Balzer, Simon Poetzsch and Winfried Brenner
    Citation: EJNMMI Radiopharmacy and Chemistry 2020 5:31
    Content type: Research article Published on:

  5. Current automated radiosynthesizers are generally optimized for producing large batches of PET tracers. Preclinical imaging studies, however, often require only a small portion of a regular batch, which cannot...

    Authors: Ksenia Lisova, Jia Wang, Philip H. Chao and R. Michael van Dam
    Citation: EJNMMI Radiopharmacy and Chemistry 2020 5:30
    Content type: Research article Published on:

  6. Gastrin Releasing Peptide receptor (GRPr)-based radioligands have shown great promise for diagnostic imaging of GRPr-positive cancers, such as prostate and breast.

    Authors: Michael Hofstetter, Euy Sung Moon, Fabio D’Angelo, Lucien Geissbühler, Ian Alberts, Ali Afshar-Oromieh, Frank Rösch, Axel Rominger and Eleni Gourni
    Citation: EJNMMI Radiopharmacy and Chemistry 2020 5:29
    Content type: Research article Published on:

  7. The AAZTA chelator and in particular its bifunctional derivative AAZTA5 was recently investigated to demonstrate unique capabilities to complex diagnostic and therapeutic trivalent radiometals under mild conditio...

    Authors: Jean-Philippe Sinnes, Ulrike Bauder-Wüst, Martin Schäfer, Euy Sung Moon, Klaus Kopka and Frank Rösch
    Citation: EJNMMI Radiopharmacy and Chemistry 2020 5:28
    Content type: Research article Published on:

  8. The chimeric monoclonal antibody (mAb) chDAB4 (APOMAB®) targets the Lupus associated (La)/Sjögren Syndrome-B (SSB) antigen, which is over-expressed in tumors but only becomes available for antibody binding in ...

    Authors: Vasilios Liapis, William Tieu, Stacey E. Rudd, Paul S. Donnelly, Nicole L. Wittwer, Michael P. Brown and Alexander H. Staudacher
    Citation: EJNMMI Radiopharmacy and Chemistry 2020 5:27
    Content type: Research article Published on:

  9. Fluorine labelled 8-((E)-4-fluoro-but-2-enyl)-3β-p-tolyl-8-aza-bicyclo[3.2.1]octane-2β-carboxylic acid methyl ester ([18F]LBT999) is a selective radioligand for the in vivo neuroimaging and quantification of the ...

    Authors: Christine Vala, Céline Mothes, Gabrielle Chicheri, Pauline Magadur, Gilles Viot, Jean-Bernard Deloye, Serge Maia, Yann Bouvet, Anne-Claire Dupont, Nicolas Arlicot, Denis Guilloteau, Patrick Emond and Johnny Vercouillie
    Citation: EJNMMI Radiopharmacy and Chemistry 2020 5:26
    Content type: Research article Published on:

  10. To optimize the direct production of 68Ga on a cyclotron, via the 68Zn(p,n)68Ga reaction using a liquid cyclotron target. We Investigated the yield of cyclotron-produced 68Ga, extraction of [68Ga]GaCl3 and subseq...

    Authors: Melissa E. Rodnick, Carina Sollert, Daniela Stark, Mara Clark, Andrew Katsifis, Brian G. Hockley, D. Christian Parr, Jens Frigell, Bradford D. Henderson, Monica Abghari-Gerst, Morand R. Piert, Michael J. Fulham, Stefan Eberl, Katherine Gagnon and Peter J. H. Scott
    Citation: EJNMMI Radiopharmacy and Chemistry 2020 5:25
    Content type: Research article Published on:

  11. In the US, EU and elsewhere, basic clinical research studies with positron emission tomography (PET) radiotracers that are generally recognized as safe and effective (GRASE) can often be conducted under instit...

    Authors: Isaac M. Jackson, So Jeong Lee, Alexandra R. Sowa, Melissa E. Rodnick, Laura Bruton, Mara Clark, Sean Preshlock, Jill Rothley, Virginia E. Rogers, Leslie E. Botti, Bradford D. Henderson, Brian G. Hockley, Jovany Torres, David M. Raffel, Allen F. Brooks, Kirk A. Frey…
    Citation: EJNMMI Radiopharmacy and Chemistry 2020 5:24
    Content type: Guideline article Published on:

  12. Oncrasin-1 is a small molecule which was identified from a screen of KRAS mutant cancer cells and has shown specificity for KRAS mutant cell killing. We aimed to develop a radiolabelled form of Oncrasin-1 to e...

    Authors: Alexander F. McDonald, Yit Wooi Goh, Jonathan M. White, Andrew M. Scott and Uwe Ackermann
    Citation: EJNMMI Radiopharmacy and Chemistry 2020 5:23
    Content type: Research article Published on:

  13. Epidermal growth factor receptors (EGFR) are overexpressed on > 90% of pancreatic cancers (PnCa) and represent an attractive target for the development of novel therapies, including radioimmunotherapy (RIT). O...

    Authors: Sadaf Aghevlian, Zhongli Cai, David Hedley, Mitchell A. Winnik and Raymond M. Reilly
    Citation: EJNMMI Radiopharmacy and Chemistry 2020 5:22
    Content type: Research article Published on:

  14. A need for improved, cassette-based automation of 61Cu separation from irradiated Ni targets was identified given the growing interest in theranostics, and generally lengthy separation chemistries for 64Cu/64Ni, ...

    Authors: Johan Svedjehed, Christopher J. Kutyreff, Jonathan W. Engle and Katherine Gagnon
    Citation: EJNMMI Radiopharmacy and Chemistry 2020 5:21
    Content type: Research article Published on:

  15. Formamides are common motifs of biologically-active compounds (e.g. formylated peptides) and are frequently employed as intermediates to yield a number of other functional groups. A rapid, simple and reliable ...

    Authors: Federico Luzi, Antony D. Gee and Salvatore Bongarzone
    Citation: EJNMMI Radiopharmacy and Chemistry 2020 5:20
    Content type: Research article Published on:

  16. Fibroblast activation protein (FAP) is a proline selective serine protease that is overexpressed in tumor stroma and in lesions of many other diseases that are characterized by tissue remodeling. In 2014, a mo...

    Authors: Euy Sung Moon, Filipe Elvas, Gwendolyn Vliegen, Stef De Lombaerde, Christel Vangestel, Sven De Bruycker, An Bracke, Elisabeth Eppard, Lukas Greifenstein, Benedikt Klasen, Vasko Kramer, Steven Staelens, Ingrid De Meester, Pieter Van der Veken and Frank Rösch
    Citation: EJNMMI Radiopharmacy and Chemistry 2020 5:19
    Content type: Research article Published on:

  17. [18F]PSMA-1007, a positron emission tomography (PET) tracer, specifically targets prostate-specific membrane antigen (PSMA), which is highly expressed in prostate cancer. PSMA-PET is effective especially for regi...

    Authors: Sadahiro Naka, Tadashi Watabe, Kenta Kurimoto, Motohide Uemura, Fumihiko Soeda, Oliver C. Neels, Klaus Kopka, Mitsuaki Tatsumi, Hiroki Kato, Norio Nonomura, Eku Shimosegawa, Jens Cardinale, Frederik L. Giesel and Jun Hatazawa
    Citation: EJNMMI Radiopharmacy and Chemistry 2020 5:18
    Content type: Research article Published on:

  18. Glycogen is a multibranched polysaccharide of glucose produced by cells to store energy and plays a key role in cancer. A previously reported fluorescent probe (CDg4) was shown to selectively bind glycogen in ...

    Authors: Louis Allott, Diana Brickute, Cen Chen, Marta Braga, Chris Barnes, Ning Wang and Eric O. Aboagye
    Citation: EJNMMI Radiopharmacy and Chemistry 2020 5:17
    Content type: Research article Published on:

  20. Copper is essential for enzymatic processes throughout the body. [64Cu]copper (64Cu) positron emission tomography (PET) has been investigated as a diagnostic tool for certain malignancies, but has not yet been us...

    Authors: Kristoffer Kjærgaard, Thomas Damgaard Sandahl, Kim Frisch, Karina Højrup Vase, Susanne Keiding, Hendrik Vilstrup, Peter Ott, Lars Christian Gormsen and Ole Lajord Munk
    Citation: EJNMMI Radiopharmacy and Chemistry 2020 5:15
    Content type: Research article Published on:

  21. In vitro experiments using radiolabeled molecules is fundamental for Positron emission tomography (PET) or single photon emission computed tomography (SPECT) tracer development and various metabolic assays, bu...

    Authors: Morten Busk, Michael R. Horsman, Jens Overgaard and Steen Jakobsen
    Citation: EJNMMI Radiopharmacy and Chemistry 2020 5:14
    Content type: Research article Published on:

  22. Serotonin 1A (5-HT1A) receptors are implicated in the pathogenesis of several psychiatric and neurodegenerative disorders motivating the development of suitable radiotracers for in vivo positron emission tomograp...

    Authors: Vidya Narayanaswami, Junchao Tong, Ferdinando Fiorino, Beatrice Severino, Rosa Sparaco, Elisa Magli, Flavia Giordano, Peter M. Bloomfield, Jaya Prabhakaran, J. John Mann, Neil Vasdev, Kenneth Dahl and J. S. Dileep Kumar
    Citation: EJNMMI Radiopharmacy and Chemistry 2020 5:13
    Content type: Research article Published on:

  23. The introduction of a GMP-certified 68Ga-generator spurred the application of 68Ga-radiopharmaceuticals. Several radiosynthesis of 68Ga-radiopharmaceuticals are more efficient and robust when performed with 2-[4-...

    Authors: I. F. Antunes, G. M. Franssen, R. Zijlma, P. Laverman, H. H. Boersma and P. H. Elsinga
    Citation: EJNMMI Radiopharmacy and Chemistry 2020 5:12
    Content type: Methodology Published on:

  24. [13N]Ammonia is a cyclotron produced myocardial perfusion imaging agent. With the development of high-yielding [13N]ammonia cyclotron targets using a solution of 5 mM ethanol in water, there was a need to develop...

    Authors: Daniel L. Yokell, Peter A. Rice, Ramesh Neelamegam and Georges El Fakhri
    Citation: EJNMMI Radiopharmacy and Chemistry 2020 5:11
    Content type: Methodology Published on:

  25. Lymph node dissection is a therapeutic option for prostate cancer patients with a high risk of- or proven lymph node metastases. Radioguided surgery after intravenous injection of [99mTc]Tc-PSMA could improve the...

    Authors: Else A. Aalbersberg, Lotte van Andel, Martine M. Geluk-Jonker, Jos H. Beijnen, Marcel P. M. Stokkel and Jeroen J. M. A. Hendrikx
    Citation: EJNMMI Radiopharmacy and Chemistry 2020 5:10
    Content type: Research article Published on:

  26. The radiochemical purity (RCP) of technetium-99m labelled radiopharmaceuticals (RP) is important to ensure optimal scintigraphic image quality. In low-income settings, it may not be possible to use compendial ...

    Authors: F. P. Ekoume, H. H. Boersma, F. Dong à Zok and S. M. Rubow
    Citation: EJNMMI Radiopharmacy and Chemistry 2020 5:9
    Content type: Methodology Published on:

  27. PentixaFor is a promising radiopharmaceutical for positron emission tomography in the detection of different tumor entities and other diseases. Until now, the synthesis of [68Ga]Ga-PentixaFor was reported for the...

    Authors: Sarah Spreckelmeyer, Oliver Schulze and Winfried Brenner
    Citation: EJNMMI Radiopharmacy and Chemistry 2020 5:8
    Content type: Methodology Published on:

  28. To fulfil good manufacturing requirements, analytical methods for the analysis of pharmaceuticals for human and vetinary use must be validated. The International Conference on Harmonization of Technical Requir...

    Authors: Nic Gillings, Sergio Todde, Martin Behe, Clemens Decristoforo, Philip Elsinga, Valentina Ferrari, Olaug Hjelstuen, Petra Kolenc Peitl, Jacek Koziorowski, Peter Laverman, Thomas L. Mindt, Meltem Ocak and Marianne Patt
    Citation: EJNMMI Radiopharmacy and Chemistry 2020 5:7
    Content type: Guideline article Published on:

  29. The IsoDAR collaboration is developing a high-current cyclotron for a neutrino search experiment. Designed to deliver 10 mA of 60 MeV protons, the current and power of this cyclotron far exceed those of existi...

    Authors: Loyd H. Waites, Jose R. Alonso, Roger Barlow and Janet M. Conrad
    Citation: EJNMMI Radiopharmacy and Chemistry 2020 5:6
    Content type: Review Published on:

  30. Here we report on the comprehensive quality control of a 4.04 GBq (109 mCi) generator supplied by itG (Munich, Germany), and used for routine production of [68Ga]Ga-PSMA-11 for clinical imaging. The performance o...

    Authors: Nicole N. Waterhouse, Alejandro Amor-Coarasa, Anastasia Nikolopoulou and John W. Babich
    Citation: EJNMMI Radiopharmacy and Chemistry 2020 5:5
    Content type: Research article Published on:

  31. Gallium-68 labeled synthetic somatostatin analogs for PET/CT imaging are the current gold standard for somatostatin receptor imaging in neuroendocrine tumor patients. Despite good imaging properties, their use...

    Authors: Térence Tshibangu, Christopher Cawthorne, Kim Serdons, Elin Pauwels, Willy Gsell, Guy Bormans, Christophe M. Deroose and Frederik Cleeren
    Citation: EJNMMI Radiopharmacy and Chemistry 2020 5:4
    Content type: Research article Published on:

  32. Targeted therapy of HER2 positive breast cancer has led to clinical success in some cases with primary and secondary resistance being major obstacles. Due to the substantial involvement of mTOR kinase in cell ...

    Authors: Christian W. Wichmann, Yit Wooi Goh, Adam C. Parslow, Angela Rigopoulos, Nancy Guo, Andrew M. Scott, Uwe Ackermann and Jonathan M. White
    Citation: EJNMMI Radiopharmacy and Chemistry 2020 5:3
    Content type: Research article Published on:

  33. Over the last several years, the use of radiometals has gained increasing relevance in supporting the continuous development of new, complementary and more specific biological targeting agents. Radiopharmaceut...

    Authors: Sergio J. C. do Carmo, Peter J. H. Scott and Francisco Alves
    Citation: EJNMMI Radiopharmacy and Chemistry 2020 5:2
    Content type: Review Published on:

  34. Conventional scale production of small batches of PET tracers (e.g. for preclinical imaging) is an inefficient use of resources. Using O-(2-[18F]fluoroethyl)-L-tyrosine ([18F]FET), we demonstrate that simple micr...

    Authors: Ksenia Lisova, Bao Ying Chen, Jia Wang, Kelly Mun-Ming Fong, Peter M. Clark and R. Michael van Dam
    Citation: EJNMMI Radiopharmacy and Chemistry 2019 5:1
    Content type: Research article Published on:

  35. [11C]Metoclopramide is a new radiotracer for investigating the activity of P-glycoprotein at the blood-brain barrier. A highly stable and reproducible radiosynthesis is a prerequisite for clinical studies applyin...

    Authors: Verena Pichler, Marius Ozenil, Karsten Bamminger, Chrysoula Vraka, Marcus Hacker, Oliver Langer and Wolfgang Wadsak
    Citation: EJNMMI Radiopharmacy and Chemistry 2019 4:31
    Content type: Research article Published on:

  36. [11C]UCB-J is a tracer developed for PET (positron emission tomography) that has high affinity towards synaptic vesicle glycoprotein 2A (SV2A), a protein believed to participate in the regulation of neurotransmit...

    Authors: Johanna Rokka, Eva Schlein and Jonas Eriksson
    Citation: EJNMMI Radiopharmacy and Chemistry 2019 4:30
    Content type: Research article Published on:

  37. Immunotherapy with checkpoint inhibitors demonstrates impressive improvements in the treatment of several types of cancer. Unfortunately, not all patients respond to therapy while severe immune-related adverse...

    Authors: Peter Wierstra, Gerwin Sandker, Erik Aarntzen, Martin Gotthardt, Gosse Adema, Johan Bussink, René Raavé and Sandra Heskamp
    Citation: EJNMMI Radiopharmacy and Chemistry 2019 4:29
    Content type: Review Published on:

  38. Copper-mediated radiofluorination is a straightforward method to produce a variety of [18F]fluoroarenes and [18F]fluoroheteroarenes. To minimize the number of steps in the production of 18F-labelled radiopharmace...

    Authors: Salla Orvokki Lahdenpohja, Noora Annika Rajala, Johan Rajander and Anna Kaarina Kirjavainen
    Citation: EJNMMI Radiopharmacy and Chemistry 2019 4:28
    Content type: Research article Published on:

  39. Auger electrons (AEs) are very low energy electrons that are emitted by radionuclides that decay by electron capture (e.g. 111In, 67Ga, 99mTc, 195mPt, 125I and 123I). This energy is deposited over nanometre-micro...

    Authors: Anthony Ku, Valerie J. Facca, Zhongli Cai and Raymond M. Reilly
    Citation: EJNMMI Radiopharmacy and Chemistry 2019 4:27
    Content type: Review Published on:

  40. Recent studies showed that ethanol in the reaction mixture improves radiolabelling with trivalent radiometals in terms of precursor amount, reaction time, reaction temperature and radiolysis. With regard to cl...

    Authors: Michael Meisenheimer, Stefan Kürpig, Markus Essler and Elisabeth Eppard
    Citation: EJNMMI Radiopharmacy and Chemistry 2019 4:26
    Content type: Research article Published on:

  41. [11C]Carbon monoxide is an appealing synthon for introducing carbon-11 at a carbonyl position (C=O) in a wide variety of chemotypes (e.g., amides, ketones, acids, esters, and ureas). The prevalence of the carbony...

    Authors: Carlotta Taddei and Victor W. Pike
    Citation: EJNMMI Radiopharmacy and Chemistry 2019 4:25
    Content type: Review Published on:

  42. PET radiopharmaceutical development and the implementation of a production method on a synthesis module is a complex and time-intensive task since new synthesis methods must be adapted to the confines of the s...

    Authors: Christopher Frank, Georg Winter, Fredrik Rensei, Victor Samper, Allen F. Brooks, Brian G. Hockley, Bradford D. Henderson, Christian Rensch and Peter J. H. Scott
    Citation: EJNMMI Radiopharmacy and Chemistry 2019 4:24
    Content type: Research article Published on:

  43. Gallium-68 ([68Ga]Ga) labelled radiopharmaceuticals have become a valuable tool in clinical practice using Positron Emission Tomography (PET). These agents are typically produced on-site owing to the short half-l...

    Authors: Mohammad B. Haskali, Peter D. Roselt, David Binns, Amit Hetsron, Stan Poniger, Craig A. Hutton and Rodney J. Hicks
    Citation: EJNMMI Radiopharmacy and Chemistry 2019 4:23
    Content type: Research article Published on:

  44. The EU directive 2001/83 describes the community code for medicinal products for human use including radiopharmaceuticals. In its current definition, also radionuclide precursors, such as fluorine-18, need to ...

    Authors: Oliver Neels, Marianne Patt and Clemens Decristoforo
    Citation: EJNMMI Radiopharmacy and Chemistry 2019 4:22
    Content type: Position paper Published on:

  45. Actinium-225 (225Ac, t1/2 = 9.9 d) is a promising candidate radionuclide for use in targeted alpha therapy (TAT), though the currently limited global supply has hindered the development of a suitable Ac-chelating...

    Authors: Caterina F. Ramogida, Andrew K. H. Robertson, Una Jermilova, Chengcheng Zhang, Hua Yang, Peter Kunz, Jens Lassen, Ivica Bratanovic, Victoria Brown, Lily Southcott, Cristina Rodríguez-Rodríguez, Valery Radchenko, François Bénard, Chris Orvig and Paul Schaffer
    Citation: EJNMMI Radiopharmacy and Chemistry 2019 4:21
    Content type: Research article Published on:

  46. Dopamine receptors are involved in pathophysiology of neuropsychiatric diseases, including Huntington’s disease (HD). PET imaging of dopamine D2 receptors (D2R) in HD patients has demonstrated 40% decrease in ...

    Authors: Tuulia Huhtala, Pekka Poutiainen, Jussi Rytkönen, Kimmo Lehtimäki, Teija Parkkari, Iiris Kasanen, Anu J. Airaksinen, Teija Koivula, Patrick Sweeney, Outi Kontkanen, John Wityak, Celia Dominiquez and Larry C. Park
    Citation: EJNMMI Radiopharmacy and Chemistry 2019 4:20
    Content type: Research article Published on:

  47. Over the years, a broad spectrum of applications of the radionuclide holmium-166 as a medical isotope has been established. The isotope holmium-166 is attractive as it emits high-energy beta radiation which ca...

    Authors: Nienke J. M. Klaassen, Mark J. Arntz, Alexandra Gil Arranja, Joey Roosen and J. Frank W. Nijsen
    Citation: EJNMMI Radiopharmacy and Chemistry 2019 4:19
    Content type: Review Published on:

  49. The term of neurodegenerative diseases covers a heterogeneous group of disorders that are distinguished by progressive degeneration of the structure and function of the nervous system such as dementias, moveme...

    Authors: Solveig Tiepolt, Marianne Patt, Gayane Aghakhanyan, Philipp M. Meyer, Swen Hesse, Henryk Barthel and Osama Sabri
    Citation: EJNMMI Radiopharmacy and Chemistry 2019 4:17
    Content type: Review Published on:

  50. Tumors form a complex environment consisting of a variety of non-malignant cells. Especially cancer-associated fibroblasts have been shown to have an important role for different aspects of malignant tumors su...

    Authors: Thomas Lindner, Anastasia Loktev, Frederik Giesel, Clemens Kratochwil, Annette Altmann and Uwe Haberkorn
    Citation: EJNMMI Radiopharmacy and Chemistry 2019 4:16
    Content type: Review Published on:
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