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  1. Terbium-155 [T1/2 = 5.32 d, Eγ = 87 keV (32%) 105 keV (25%)] is an interesting radionuclide suitable for single photon emission computed tomography (SPECT) imaging with potential application in the diagnosis of o...

    Authors: C. Favaretto, Z. Talip, F. Borgna, P. V. Grundler, G. Dellepiane, A. Sommerhalder, H. Zhang, R. Schibli, S. Braccini, C. Müller and N. P. van der Meulen

    Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:37

    Content type: Research article

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  2. Prostate-specific membrane antigen is overexpressed in prostate cancer and it is considered a good target for positron emission tomography/computed tomography imaging of primary cancer and recurrent/metastatic...

    Authors: Costantina Maisto, Anna Morisco, Roberta de Marino, Elisabetta Squame, Valentina Porfidia, Laura D’Ambrosio, Daria Di Martino, Paolo Gaballo, Michela Aurilio, Monica Buonanno, Aureliana Esposito, Marco Raddi and Secondo Lastoria

    Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:36

    Content type: Research article

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  3. Nanocolloidal human serum albumin radiolabelled with 99mTc provides a diagnostic radiopharmaceutical for sentinel node lymphoscintigraphy. NanoHSA (Nanotop), a commercially available kit, enables the simple prepa...

    Authors: Ruslan Cusnir, Michel Leresche, Claude Pilloud and Marietta Straub

    Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:35

    Content type: Research article

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  4. This guideline on molar activity (Am) and specific activity (As) focusses on small molecules, peptides and macromolecules radiolabelled for diagnostic and therapeutic applications. In this guideline we describe t...

    Authors: Gert Luurtsema, Verena Pichler, Salvatore Bongarzone, Yann Seimbille, Philip Elsinga, Antony Gee and Johnny Vercouillie

    Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:34

    Content type: Guideline article

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  5. Positron emission tomography (PET) has become an invaluable tool for drug discovery and diagnosis. The positron-emitting radionuclide fluorine-18 is frequently used in PET radiopharmaceuticals due to its advan...

    Authors: Javier Ajenjo, Gianluca Destro, Bart Cornelissen and Véronique Gouverneur

    Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:33

    Content type: Review

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  6. The Editorial Board of EJNMMI Radiopharmacy and Chemistry releases a biyearly highlight commentary to update the readership on trends in the field of radiopharmaceutical development.

    Authors: Francisco Alves, Inês F. Antunes, Emiliano Cazzola, Frederik Cleeren, Bart Cornelissen, Antonia Denkova, Jonathan Engle, Alain Faivre-Chauvet, Nic Gillings, Jeroen J. M. A. Hendrikx, Amir R. Jalilian, Nicholas P. van der Meulen, Renata Mikolajczak, Oliver C. Neels, Maroor R. A. Pillai, Raymond Reilly…

    Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:31

    Content type: Review

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  7. The aluminium-[18F]fluoride ([18F]AlF) radiolabelling method combines the favourable decay characteristics of fluorine-18 with the convenience and familiarity of metal-based radiochemistry and has been used to pa...

    Authors: Stephen J. Archibald and Louis Allott

    Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:30

    Content type: Review

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    The Correction to this article has been published in EJNMMI Radiopharmacy and Chemistry 2021 6:32

  8. Elevated kidney uptake in insulinoma patients remains a major limitation of radiometallated exendin-derived ligands of the glucagon-like peptide 1 receptor (GLP-1R). Based on the previously published potent GL...

    Authors: Veronika Barbara Felber and Hans-Jürgen Wester

    Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:29

    Content type: Research article

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  9. Fibroblast activation protein (FAP) is overexpressed in the stroma of many types of cancer. [18F]AlF-FAPI-74 is a positron emission tomography tracer with high selectivity for FAP, which has already shown high ac...

    Authors: Sadahiro Naka, Tadashi Watabe, Thomas Lindner, Jens Cardinale, Kenta Kurimoto, Melissa Moore, Mitsuaki Tatsumi, Yuriko Mori, Eku Shimosegawa, Frank Valla Jr., Hiroki Kato and Frederik L. Giesel

    Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:28

    Content type: Methodology

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  10. Patients with chronic kidney disease (CKD) may need to have their radiopharmaceutical dosage adjusted to prevent adverse effects and poor outcomes, but there are few recommendations on radiopharmaceutical dosi...

    Authors: Nanno Schreuder, Iris de Romijn, Pieter L. Jager, Jos G. W. Kosterink and Eugène P. van Puijenbroek

    Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:27

    Content type: Review

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  11. Cancer-associated fibroblasts are found in the stroma of epithelial tumors. They are characterized by overexpression of the fibroblast activation protein (FAP), a serine protease which was already proven as at...

    Authors: Thomas Lindner, Annette Altmann, Frederik Giesel, Clemens Kratochwil, Christian Kleist, Susanne Krämer, Walter Mier, Jens Cardinale, Hans-Ulrich Kauczor, Dirk Jäger, Jürgen Debus and Uwe Haberkorn

    Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:26

    Content type: Research article

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  12. Epidermal growth factor receptors (EGFR) are overexpressed on many head and neck squamous cell carcinoma (HNSCC). Radioimmunotherapy (RIT) with F(ab')2 of the anti-EGFR monoclonal antibody panitumumab labeled wit...

    Authors: Anthony Ku, Misaki Kondo, Zhongli Cai, Jalna Meens, Min Rong Li, Laurie Ailles and Raymond M. Reilly

    Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:25

    Content type: Research article

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  13. [18F]MC225 is a radiotracer for imaging P-glycoprotein (P-gp) function at the blood-brain barrier. The P-gp function can be altered due to different factors, for instance, decreased P-gp function has been describ...

    Authors: Lara Garcia-Varela, Khaled Attia, John Carlo Sembrano, Olivier Jacquet, Inês F. Antunes, Chantal Kwizera, Ton J. Visser, Rudi A. J. O. Dierckx, Philip H. Elsinga and Gert Luurtsema

    Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:24

    Content type: Research article

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  14. [18F]Fluoromisonidazole ([18F]FMISO) and 1-[18F]fluoro-3-((2-((1E,3E)-4-(6-(methylamino)pyridine-3-yl)buta-1,3-dien-1-yl)benzo[d]thiazol-6-yl)oxy)propan-2-ol ([18F]PM-PBB3 or [18F]APN-1607) are clinically used ra...

    Authors: Takayuki Ohkubo, Yusuke Kurihara, Masanao Ogawa, Nobuki Nengaki, Masayuki Fujinaga, Wakana Mori, Katsushi Kumata, Masayuki Hanyu, Kenji Furutsuka, Hiroki Hashimoto, Kazunori Kawamura and Ming-Rong Zhang

    Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:23

    Content type: Research article

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  15. [68Ga]Ga-NeoB is a novel DOTA-coupled Gastrin Releasing Peptide Receptor (GRPR) antagonist with high affinity for GRPR and good in vivo stability. This study aimed at (1) the translation of preclinical results to...

    Authors: Marc Pretze, Laura Reffert, Steffen Diehl, Stefan O. Schönberg, Carmen Wängler, Peter Hohenberger and Björn Wängler

    Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:22

    Content type: Research article

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  16. The radiofluorinated levodopa analogue 6-[18F]F-l-DOPA (3,4-dihydroxy-6-18F-l-phenylalanine) is a commonly employed radiotracer for PET/CT imaging of multiple oncological and neurological indications. An unusuall...

    Authors: Valdemar L. Andersen, Mikkel A. Soerensen, Johan Hygum Dam, Niels Langkjaer, Henrik Petersen, Dirk Andreas Bender, Dan Fugloe and Tri Hien Viet Huynh

    Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:21

    Content type: Research article

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  17. The translocator protein 18 kDa is recognised as an important biomarker for neuroinflammation due to its soaring expression in microglia. This process is common for various neurological disorders. DPA-714 is a...

    Authors: Klaudia A. Cybulska, Vera Bloemers, Lars R. Perk and Peter Laverman

    Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:20

    Content type: Research article

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  18. In the frame of “precision medicine”, the scandium radionuclides have recently received considerable interest, providing personalised adjustment of radiation characteristics to optimize the efficiency of medic...

    Authors: R. Mikolajczak, S. Huclier-Markai, C. Alliot, F. Haddad, D. Szikra, V. Forgacs and P. Garnuszek

    Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:19

    Content type: Review

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  19. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Ângela C. B. Neves, Ivanna Hrynchak, Inês Fonseca, Vítor H. P. Alves, Mariette M. Pereira, Amílcar Falcão and Antero J. Abrunhosa

    Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:18

    Content type: Correction

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    The original article was published in EJNMMI Radiopharmacy and Chemistry 2021 6:11

  20. To the best of our knowledge, manually production of [177Lu]Lu-FAPI radiopharmaceutical derivatives has been only described in literature. In this work, a fully-automated [177Lu]Lu-FAPI synthesis has been well de...

    Authors: Kurtulus Eryilmaz and Benan Kilbas

    Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:16

    Content type: Research article

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    The Correction to this article has been published in EJNMMI Radiopharmacy and Chemistry 2021 6:17

  21. HEPES (4-(2-hydroxyethyl) piperazine-1-ethanesulfonic acid) is a buffer that is used in the radiolabelling of gallium-68 compounds. The beneficial effects of HEPES on molar activity in bioconjugates have been ...

    Authors: Jannie le Roux, Janke Kleynhans and Sietske Rubow

    Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:15

    Content type: Letter to the Editor

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  22. The stability of precursors and reagents is of utmost importance for developing a robust radiolabelling method that provides high and constant radiochemical yield and radiochemical purity.

    Authors: Antonella Iudicello, Filippo Genovese, Valentina Di Iorio, Gianfranco Cicoria and Stefano Boschi

    Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:14

    Content type: Research article

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  23. The Editorial Board of EJNMMI Radiopharmacy and Chemistry releases a biyearly highlight commentary to update the readership on trends in the field of radiopharmaceutical development.

    Authors: Silvio Aime, Mohammed Al-Qahtani, Martin Behe, Guy Bormans, Giuseppe Carlucci, Jean N. DaSilva, Clemens Decristoforo, Adriano Duatti, Philip H. Elsinga, Klaus Kopka, Xiang-Guo Li, Zhibo Liu, Robert H. Mach, Oskar Middel, Jan Passchier, Marianne Patt…

    Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:13

    Content type: Review

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  24. There is a need to develop new and more potent radiofluorinated peptide and their hybrid conjugates for multiple-receptors targeting properties that overexpress on many cancers.

    Authors: I. Al Jammaz, B. Al-Otaibi, Y. Al-Malki, A. Abousekhrah and S. M. Okarvi

    Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:12

    Content type: Research article

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  25. The neurotracer 6-[18F]FDOPA has been, for many years, a powerful tool in PET imaging of neuropsychiatric diseases, movement disorders and brain malignancies. More recently, it also demonstrated good results in t...

    Authors: Ângela C. B. Neves, Ivanna Hrynchak, Inês Fonseca, Vítor H. P. Alves, Mariette M. Pereira, Amílcar Falcão and Antero J. Abrunhosa

    Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:11

    Content type: Review

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    The Correction to this article has been published in EJNMMI Radiopharmacy and Chemistry 2021 6:18

  26. To investigate whether modifications of prostate-specific membrane antigen (PSMA)-targeted radiolabeled urea-based inhibitors could reduce salivary gland uptake and thus improve tumor-to-salivary gland ratios,...

    Authors: Veronika Barbara Felber, Manuel Amando Valentin and Hans-Jürgen Wester

    Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:10

    Content type: Research article

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  27. Increased vascular permeability is an early sign of vascular damage and can be measured with the transcapillary escape rate of albumin (TERalb). Although TERalb has a multi-exponential kinetic model, most publish...

    Authors: Youssef Chahid, Nienke M. G. Rorije, Soufian el Boujoufi, Ron A. A. Mathôt, Liffert Vogt and Hein J. Verberne

    Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:9

    Content type: Research article

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  28. This guideline on current good radiopharmacy practice (cGRPP) for small-scale preparation of radiopharmaceuticals represents the view of the Radiopharmacy Committee of the European Association of Nuclear Medic...

    Authors: Nic Gillings, Olaug Hjelstuen, Jim Ballinger, Martin Behe, Clemens Decristoforo, Philip Elsinga, Valentina Ferrari, Petra Kolenc Peitl, Jacek Koziorowski, Peter Laverman, Thomas L. Mindt, Oliver Neels, Meltem Ocak, Marianne Patt and Sergio Todde

    Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:8

    Content type: Guideline article

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  29. The understanding of the role of different immune cell subsets that infiltrate tumors can help researchers in developing new targeted immunotherapies to reactivate or reprogram them against cancer. In addition...

    Authors: Filippo Galli, Michela Varani, Chiara Lauri, Guido Gentiloni Silveri, Livia Onofrio and Alberto Signore

    Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:7

    Content type: Review

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  30. Lead-212 (212Pb, t1/2 = 10.6 h) and lead-203 (203Pb, t1/2 = 51.9 h) are an element-equivalent, or a matched theranostic radioisotope pair that show great potential for application in targeted radionuclide therapy...

    Authors: Brooke L. McNeil, Andrew K. H. Robertson, Winnie Fu, Hua Yang, Cornelia Hoehr, Caterina F. Ramogida and Paul Schaffer

    Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:6

    Content type: Research article

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  31. The Editorial Board of EJNMMI Radiopharmacy and Chemistry releases a biyearly highlight commentary to describe trends in the field.

    Authors: Mohammed Al-Qahtani, Martin Behe, Guy Bormans, Giuseppe Carlucci, Jean Dasilva, Clemens Decristoforo, Philip H. Elsinga, Klaus Kopka, Xiang-Guo Li, Robert Mach, Oskar Middel, Jan Passchier, Marianne Patt, Ivan Penuelas, Ana Rey, Peter J. H. Scott…

    Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:5

    Content type: Review

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  32. The radiohybrid (rh) prostate-specific membrane antigen (PSMA)-targeted ligand [18F]Ga-rhPSMA-7 has previously been clinically assessed and demonstrated promising results for PET-imaging of prostate cancer. The l...

    Authors: Alexander Wurzer, Daniel Di Carlo, Michael Herz, Antonia Richter, Stephanie Robu, Ralf Schirrmacher, Alba Mascarin, Wolfgang Weber, Matthias Eiber, Markus Schwaiger and Hans-Juergen Wester

    Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:4

    Content type: Research article

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  33. 64Cu is one of the few radioisotopes that can be used for both imaging and therapy, enabling theranostics with identical chemical composition. Development of stable chelators is essential to harness the potentia....

    Authors: Hua Yang, Feng Gao, Brooke McNeil, Chengcheng Zhang, Zheliang Yuan, Stefan Zeisler, Joel Kumlin, Jutta Zeisler, François Bénard, Caterina Ramogida and Paul Schaffer

    Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:3

    Content type: Research article

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  34. The purpose of this work was to design, validate and implement a media-fill test combined with fluorescein (MFT-F) for the specific qualification and training of radiopharmacy operators, in accordance with Uni...

    Authors: Cyril Fersing, Emmanuel Deshayes, Sarah Langlet, Laurence Calas, Vincent Lisowski and Pierre Olivier Kotzki

    Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:2

    Content type: Guideline article

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  35. With increasing clinical demand for gallium-68, commercial germanium-68/gallium-68 ([68Ge]Ge/[68Ga]Ga) generators are incapable of supplying sufficient amounts of the short-lived daughter isotope. In this study, ...

    Authors: Helge Thisgaard, Joel Kumlin, Niels Langkjær, Jansen Chua, Brian Hook, Mikael Jensen, Amir Kassaian, Stefan Zeisler, Sogol Borjian, Michael Cross, Paul Schaffer and Johan Hygum Dam

    Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:1

    Content type: Research article

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  36. [68Ga]Ga-FAPI-46 is a promising radiopharmaceutical for in vivo detection of the fibroblast activation protein by positron emission tomography. Until now, the synthesis of [68Ga]Ga-FAPI-46 has been only performed...

    Authors: Sarah Spreckelmeyer, Matthias Balzer, Simon Poetzsch and Winfried Brenner

    Citation: EJNMMI Radiopharmacy and Chemistry 2020 5:31

    Content type: Research article

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  37. Current automated radiosynthesizers are generally optimized for producing large batches of PET tracers. Preclinical imaging studies, however, often require only a small portion of a regular batch, which cannot...

    Authors: Ksenia Lisova, Jia Wang, Philip H. Chao and R. Michael van Dam

    Citation: EJNMMI Radiopharmacy and Chemistry 2020 5:30

    Content type: Research article

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  38. Gastrin Releasing Peptide receptor (GRPr)-based radioligands have shown great promise for diagnostic imaging of GRPr-positive cancers, such as prostate and breast.

    Authors: Michael Hofstetter, Euy Sung Moon, Fabio D’Angelo, Lucien Geissbühler, Ian Alberts, Ali Afshar-Oromieh, Frank Rösch, Axel Rominger and Eleni Gourni

    Citation: EJNMMI Radiopharmacy and Chemistry 2020 5:29

    Content type: Research article

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  39. The AAZTA chelator and in particular its bifunctional derivative AAZTA5 was recently investigated to demonstrate unique capabilities to complex diagnostic and therapeutic trivalent radiometals under mild conditio...

    Authors: Jean-Philippe Sinnes, Ulrike Bauder-Wüst, Martin Schäfer, Euy Sung Moon, Klaus Kopka and Frank Rösch

    Citation: EJNMMI Radiopharmacy and Chemistry 2020 5:28

    Content type: Research article

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  40. The chimeric monoclonal antibody (mAb) chDAB4 (APOMAB®) targets the Lupus associated (La)/Sjögren Syndrome-B (SSB) antigen, which is over-expressed in tumors but only becomes available for antibody binding in ...

    Authors: Vasilios Liapis, William Tieu, Stacey E. Rudd, Paul S. Donnelly, Nicole L. Wittwer, Michael P. Brown and Alexander H. Staudacher

    Citation: EJNMMI Radiopharmacy and Chemistry 2020 5:27

    Content type: Research article

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  41. Fluorine labelled 8-((E)-4-fluoro-but-2-enyl)-3β-p-tolyl-8-aza-bicyclo[3.2.1]octane-2β-carboxylic acid methyl ester ([18F]LBT999) is a selective radioligand for the in vivo neuroimaging and quantification of the ...

    Authors: Christine Vala, Céline Mothes, Gabrielle Chicheri, Pauline Magadur, Gilles Viot, Jean-Bernard Deloye, Serge Maia, Yann Bouvet, Anne-Claire Dupont, Nicolas Arlicot, Denis Guilloteau, Patrick Emond and Johnny Vercouillie

    Citation: EJNMMI Radiopharmacy and Chemistry 2020 5:26

    Content type: Research article

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  42. To optimize the direct production of 68Ga on a cyclotron, via the 68Zn(p,n)68Ga reaction using a liquid cyclotron target. We Investigated the yield of cyclotron-produced 68Ga, extraction of [68Ga]GaCl3 and subseq...

    Authors: Melissa E. Rodnick, Carina Sollert, Daniela Stark, Mara Clark, Andrew Katsifis, Brian G. Hockley, D. Christian Parr, Jens Frigell, Bradford D. Henderson, Monica Abghari-Gerst, Morand R. Piert, Michael J. Fulham, Stefan Eberl, Katherine Gagnon and Peter J. H. Scott

    Citation: EJNMMI Radiopharmacy and Chemistry 2020 5:25

    Content type: Research article

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  43. In the US, EU and elsewhere, basic clinical research studies with positron emission tomography (PET) radiotracers that are generally recognized as safe and effective (GRASE) can often be conducted under instit...

    Authors: Isaac M. Jackson, So Jeong Lee, Alexandra R. Sowa, Melissa E. Rodnick, Laura Bruton, Mara Clark, Sean Preshlock, Jill Rothley, Virginia E. Rogers, Leslie E. Botti, Bradford D. Henderson, Brian G. Hockley, Jovany Torres, David M. Raffel, Allen F. Brooks, Kirk A. Frey…

    Citation: EJNMMI Radiopharmacy and Chemistry 2020 5:24

    Content type: Guideline article

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  44. Oncrasin-1 is a small molecule which was identified from a screen of KRAS mutant cancer cells and has shown specificity for KRAS mutant cell killing. We aimed to develop a radiolabelled form of Oncrasin-1 to e...

    Authors: Alexander F. McDonald, Yit Wooi Goh, Jonathan M. White, Andrew M. Scott and Uwe Ackermann

    Citation: EJNMMI Radiopharmacy and Chemistry 2020 5:23

    Content type: Research article

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  45. Epidermal growth factor receptors (EGFR) are overexpressed on > 90% of pancreatic cancers (PnCa) and represent an attractive target for the development of novel therapies, including radioimmunotherapy (RIT). O...

    Authors: Sadaf Aghevlian, Zhongli Cai, David Hedley, Mitchell A. Winnik and Raymond M. Reilly

    Citation: EJNMMI Radiopharmacy and Chemistry 2020 5:22

    Content type: Research article

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  46. A need for improved, cassette-based automation of 61Cu separation from irradiated Ni targets was identified given the growing interest in theranostics, and generally lengthy separation chemistries for 64Cu/64Ni, ...

    Authors: Johan Svedjehed, Christopher J. Kutyreff, Jonathan W. Engle and Katherine Gagnon

    Citation: EJNMMI Radiopharmacy and Chemistry 2020 5:21

    Content type: Research article

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  47. Formamides are common motifs of biologically-active compounds (e.g. formylated peptides) and are frequently employed as intermediates to yield a number of other functional groups. A rapid, simple and reliable ...

    Authors: Federico Luzi, Antony D. Gee and Salvatore Bongarzone

    Citation: EJNMMI Radiopharmacy and Chemistry 2020 5:20

    Content type: Research article

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  48. Fibroblast activation protein (FAP) is a proline selective serine protease that is overexpressed in tumor stroma and in lesions of many other diseases that are characterized by tissue remodeling. In 2014, a mo...

    Authors: Euy Sung Moon, Filipe Elvas, Gwendolyn Vliegen, Stef De Lombaerde, Christel Vangestel, Sven De Bruycker, An Bracke, Elisabeth Eppard, Lukas Greifenstein, Benedikt Klasen, Vasko Kramer, Steven Staelens, Ingrid De Meester, Pieter Van der Veken and Frank Rösch

    Citation: EJNMMI Radiopharmacy and Chemistry 2020 5:19

    Content type: Research article

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