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Table 5 Clinical PET studies using [18F]AlF-NOTA-PRGD2 (18F-Alfatide) and [18F]AlF-NOTA-E[PEG4-c(RGDfK)]2 (18F-Alfatide II)

From: The aluminium-[18F]fluoride revolution: simple radiochemistry with a big impact for radiolabelled biomolecules

Year Study No
Participants
Outcome References
[18F]AlF-NOTA-PRGD2 (18F-Alfatide)
 2013 Lung cancer 9 All tumours visualised Wan et al. (2013)
 2014 Differentiated thyroid cancer (DTC) 20 Most lymph node metastases showed abnormal uptake of the radioconjugate, but the diagnostic value was inferior to [18F]FDG Cheng et al. (2014)
 2015 Lung cancer 26 Successfully differentiated malignant lesions from hamartoma. Challenging to differentiate inflammatory or inflammatory pseudotumours from malignancy Gao et al. (2015)
 2016 Advanced non-small cell lung cancer (NSCLC) 18 May predict short-term outcome of concurrent chemoradiotherapy in patients with advanced NSCLC Luan et al. (2016)
 2016 Glioblastoma (GBM) 25 Visualisation of GBM and predictive of sensitivity to concurrent chemoradiotherapy as early as 3 weeks after treatment Zhang et al. (2016)
 2017 Lymph node metastases in NSCLC 13 Highly sensitive, specific and accurate detection of metastatic lymph nodes for NSCLC patients Zhou et al. (2017)
 2019 Esophageal Squamous Cell Carcinoma (ESCC) 61 No significant differences in uptake between 18F-Alfatide and [18F]FDG were observed, but may provide a complementary information about ESCC metastasis Dong et al. (2019)
 2019 Response to apatinib 38 High uptake in tumours correlated with a better response to apatinib therapy and may be of predictive value Li et al. (2019)
[18F]AlF-NOTA-E[PEG4-c(RGDfK)]2 (18F-Alfatide II)
 2015 Healthy Volunteers 5 Well tolerated with no serious adverse events Yu et al. (2015)
 2015 Brain metastases 9 All brain lesions were visualised Yu et al. (2015)
 2015 Bone metastasis 30 Sensitivity in osteoblastic metastases was low but significantly higher than for [18F]FDG Mi et al. (2015)
 2018 Breast Cancer 44 Good performance but not superior to [18F]FDG in identifying breast cancer in this study. May have superiority in detecting strongly ER + ve and HER2-ve expression Wu et al. (2018)
 2018 Lung cancer & Tuberculosis (TB) 20 The radioconjugate was able to differentiate between lung cancer and TB Du et al. (2018)