Optimization and scale up of production of the PSMA imaging agent [18F]AlF-P16-093 on a custom automated radiosynthesis platform

EJNMMI Radiopharmacy and Chemistry

Table 4 Large-scale [¹⁸F]AlF²⁺ labeling of acyclic chelators conjugated with an urea-based PSMA inhibitor

Machine Reference	Compound	AlCl₃nmol	Ligand nmol	Product (GBq)	EOS yield (%)*	Molar activity (GBq/µmole)	Purification	Time (min)
SynthraFCHOL Kersemans (2018)	PSMA-11	100	200	24 ± 6	21 ± 3%	120 ± 28	SPE (HLB × 2) 360 mg	35
TracerLab FX Giglio (2018)	PSMA-11	45	60	2.7–17.4	18%	58–544	Semi-prep HPLC	Not reported
Custom remote Cleeren (2016)	Glu-NH-CO–NH-Lys(Ahx)L3	100	300	8.14	25%***	27	Semi-prep HPLC	35**
PiBOX	P16-093	80	160	17.5 ± 2.2	52 ± 4%	109 ± 14	SPE (HLB × 1) 150 mg	30
PiBOX	P16-093	80	120	16.7 ± 1.3	49 ± 5%	140 ± 11	SPE (HLB × 1) 150 mg	30