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EJNMMI Radiopharmacy and Chemistry

Table 3 Results from optimization runs using 3 different PiBOX machines

From: Optimization and scale up of production of the PSMA imaging agent [18F]AlF-P16-093 on a custom automated radiosynthesis platform

QMA type

Eluent

N

Efficiency

P-QMA*

P-Eluent*

QMA carb

33%

5

85.8 ± 1.7%

  

QMA (Cl−)

33%

15

91.2 ± 2.0%

 < 0.00005

 

QMA carb

20%

19

90.5 ± 2.0%

 

 < 0.001

QMA (Cl−)

20%

27

92.4 ± 1.6%

 < 0.002

 < 0.05

  1. *A Student T-Test was used to compare efficiencies between QMA types for the same eluent composition (P-QMA), and between eluent compositions for the same QMA type (P-Eluent). Eluent percent is percent ethanol in a 0.7 mL mixture with pH 4.5 0.5 M NaOAc buffer
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