Optimization and scale up of production of the PSMA imaging agent [18F]AlF-P16-093 on a custom automated radiosynthesis platform

EJNMMI Radiopharmacy and Chemistry

Table 2 Results from scaled up production runs using optimized conditions

Run	P16-093 (nmol)	AlCl₃·6H₂O (nmol)	Starting F18 (GBq)	Product F18 (GBq)	EOS %	RCY.LS_qma %	Molar activity* (GBq/µmole)	Radio-Purity %
1	160	80	31.5	15	48	67	94	98
2	160	80	33.2	18.3	55	75	114	99
3	160	80	35.5	19.3	54	73	120	99
4	120	80	32	17	54	73	145	98
5	120	80	38	18	47	64	147	97
6	120	80	34	15	45	61	127	97

*Molar activity is calculated assuming 100% of the starting P16-093 mass is in the final product vial. Radiochemical purity was determined by TLC. EOS (End of Synthesis) is the not decay corrected yield