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EJNMMI Radiopharmacy and Chemistry

Table 2 Apparent equilibrium dissociation (KD) constants for the interaction between 99mTc-labelled Affibody molecules and B7-H3-expressing SKOV-3 cells determined using an Interaction Map analysis of the LigandTracer sensorgrams.* Data are taken from (Oroujeni et al. 2022, 2023)

From: Comparison of approaches for increasing affinity of affibody molecules for imaging of B7-H3: dimerization and affinity maturation

 

KD1 (nM)

Weight1, %

KD2 (nM)

Weight2, %

[99mTc]Tc-ZAC12-GGGC*

1.9 ± 0.8

23

68.8 ± 7.4

67

[99mTc]Tc-ZAC12*-ZAC12*-GGGC

0.28 ± 0.10

68

15.2 ± 6.3

32

[99mTc]Tc-ZAC12*-ZTaq_3-GGGC

2.1 ± 0.9

100

-

-

[99mTc]Tc-SYNT-179*

0.028 ± 0.001

12

8.2 ± 0.5

88

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