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EJNMMI Radiopharmacy and Chemistry
Fig. 1 | EJNMMI Radiopharmacy and Chemistry

Fig. 1

From: Improved automated one-pot two-step radiosynthesis of (S)-[18F]FETrp, a radiotracer for PET imaging of indoleamine 2,3-dioxygenase 1 (IDO1)

Fig. 1

Synthesis of references (S)- and (R)-FETrp and corresponding precursors (S)- and (R)-3. (a) BTEAC, anhyd. K2CO3, t-BuBr, anhyd. DMA, 55 °C, 5.5 h; (b) (i) NaH 60 wt%, anhyd. DMF, 0 °C, 5 min; (ii) 2-fluoroethyl tosylate (1), 0 °C, 50 min; (c) (i) KOtBu 1 M in anhyd. THF, anhyd. DMF, rt; (ii) 2-fluoroethyl tosylate (1), 0 °C, 1.5 h; (d) HCl 2.5 M in anhyd. Et2O, anhyd. CH2Cl2, rt, 3 h; (e) (i) KOtBu 1 M in anhyd. THF, anhyd. DMF, rt; (ii) benzyl 2-bromoethyl ether, 0 °C, 1 h; (f) BTEAC, anhyd. K2CO3, t-BuBr, anhyd. DMA, 55 °C, 5 h; (g) H2, Pd/C 10 wt%, MeOH, rt, 2–24 h; (h) TsCl, TEA, DMAP, anhyd. CH2Cl2, 0 °C, 30 min then, rt, 20 h

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