Skip to main content

Table 2 Biodistribution at 1 h and 3 h Post-injection in Tumor-Bearing Micea

From: Neopentyl glycol-based radiohalogen-labeled amino acid derivatives for cancer radiotheranostics

 

[211At]At-NpGT

[125I]I-NpGT

[18F]F-NpGT

[125I]I-IMT

Time after Injection

1 h

3 h

1 h

3 h

1 h

3 h

1 h

3 h

Blood

1.39 ± 0.33 c

0.49 ± 0.09

1.86 ± 0.09

0.54 ± 0.27

1.91 ± 0.35

0.37 ± 0.10

1.22 ± 0.24f,g

0.22 ± 004e,f

Liver

8.09 ± 1.34

2.25 ± 0.55

8.09 ± 1.22

2.94 ± 1.63

7.28 ± 1.30

1.40 ± 0.53

0.80 ± 0.20f,g

0.14 ± 0.04e,f

Spleen

2.22 ± 0.58

0.94 ± 0.17b

2.30 ± 0.58

0.56 ± 0.24

2.36 ± 0.68

0.63 ± 0.20

1.01 ± 0.22f,e,g

0.16 ± 0.05e,f,g

Kidney

32.8 ± 5.23c

14.8 ± 3.41c

25.0 ± 4.25d

10.4 ± 4.42d

13.5 ± 3.58

4.06 ± 1.53

19.6 ± 3.37

2.34 ± 0.31e,f

Pancreas

16.6 ± 1.03b

3.33 ± 1.17

30.1 ± 3.05

7.36 ± 4.07

20.3 ± 4.20

8.54 ± 2.55

11.9 ± 4.48 f

0.56 ± 0.21f,g

Heart

1.09 ± 0.20

0.74 ± 0.73

1.36 ± 0.20

0.43 ± 0.18

1.16 ± 0.30

0.56 ± 0.11

1.12 ± 0.29

0.11 ± 0.03

Lung

2.46 ± 0.41c

1.59 ± 1.10

2.14 ± 0.37d

0.58 ± 0.22

1.89 ± 0.35

0.65 ± 0.17

1.00 ± 0.39 e, f

0.17 ± 0.03e

Muscle

0.95 ± 0.53

0.42 ± 0.07

0.96 ± 0.14

0.59 ± 0.27

0.48 ± 0.08

0.62 ± 0.48

1.10 ± 0.28

0.27 ± 0.09

Bone

0.81 ± 0.23

0.44 ± 0.12

1.14 ± 0.01

0.42 ± 0.16

0.83 ± 0.22

0.58 ± 0.42

0.87 ± 0.06

0.14 ± 0.02

Tumor

2.72 ± 0.63

0.86 ± 0.23c

2.97 ± 0.58

0.99 ± 0.37

2.95 ± 0.40

1.46 ± 0.33

2.07 ± 0.23 g

0.25 ± 0.03e,f,g

Tumor/Blood

2.02 ± 0.51

1.73 ± 0.26c

1.59 ± 0.28

1.98 ± 0.39d

1.56 ± 0.15

3.96 ± 0.26

1.74 ± 0.35

1.17 ± 0.31e,f,g

Intestine*

5.56 ± 0.77c

5.88 ± 0.98c

5.12 ± 1.23

7.89 ± 3.22d

4.07 ± 0.25

2.60 ± 0.21

1.67 ± 0.49e,f,g

0.85 ± 0.21f

Stomach*

1.03 ± 0.20

0.88 ± 0.28c

1.22 ± 0.62

0.65 ± 0.43

1.03 ± 0.52

0.19 ± 0.07

0.94 ± 0.36

0.61 ± 0.38

Neck*

0.09 ± 0.02

0.11 ± 0.03

0.03 ± 0.01

0.09 ± 0.03

0.02 ± 0.01

0.01 ± 0.00

0.35 ± 0.06e,f,g

0.54 ± 0.11e,f,g

  1. aTissue radioactivity was expressed as %ID/g ± SD for each group (n = 5)
  2. *Tissue radioactivity was expressed as %ID. Statistical analysis was performed using on-way ANOVA followed by Tukey’s test between [211At]At-NpGT and [125I]I-NpGT (b), [211At]At-NpGT and [18F]F-NpGT (c), [125I]I-NpGT and [18F]F-NpGT (d), [211At]At-NpGT and [125I]I-IMT (e), [125I]I-NpGT and [125I]-IMT (f), and [18F]F-NpGT and [125I]I-IMT (g)