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Table 1 Rate of cellular internalisation of [177Lu]Lu-DOTA-C595 over 48 h

From: In vitro characterisation of [177Lu]Lu-DOTA-C595 as a novel radioimmunotherapy for MUC1-CE positive pancreatic cancer

Cell line

Mean internalised activity ± S.D. (%)

p value compared to PANC-1

1 h

18 h

24 h

48 h

PANC-1

28.415 ± 1.833

61.499 ± 3.572

67.983 ± 1.155

75.370 ± 3.554

CAPAN-1

16.295 ± 2.773

p = 0.0162*

27.492 ± 2.905

p = 0.0009***

30.036 ± 12.683

p = 0.0848

39.201 ± 2.803

p = 0.0007***

BxPC-3

19.025 ± 3.054

p = 0.0492*

27.776 ± 2.611

p = 0.0011**

31.968 ± 1.736

p < 0.0001****

47.312 ± 3.629

p = 0.0023**

AsPC-1

15.927 ± 1.916

p = 0.0045**

30.332 ± 1.740

p = 0.0031**

40.933 ± 3.593

p = 0.0084**

54.872 ± 13.186

p = 0.2588

  1. Displayed p-values were computed using Tukey’s Test and compared to PANC-1 cells at corresponding time point
  2. *p < 0.05, **p < 0.01, ***p < 0.001 and ****p < 0.0001