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Table 3 [11C]OHB kinetics (intravenous administration)

From: Intravenous and oral whole body ketone dosimetry, biodistribution, metabolite correction and kinetics studied by (R)-[1-11C]β-hydroxybutyrate ([11C]OHB) PET in healthy humans

 

K1 (mL/mL/min)

k2 (1/min)

k3 (1/min)

k4 (1/min)

Ki (mL/100 g/min)

Vt (mL/mL)

Heart wall 2 T

0.49 \(\pm \hspace{0.17em}\)0.20

0.42 \(\pm \hspace{0.17em}\)0.35

0.18 \(\pm \hspace{0.17em}\)0.14

0.16 \(\pm \hspace{0.17em}\)0.03

13.85 \(\pm \hspace{0.17em}\)2.69

3.03 \(\pm \hspace{0.17em}\)0.47

Skeletal muscle 2T

0.04 \(\pm \hspace{0.17em}\)0.03

0.19 \(\pm \hspace{0.17em}\)0.15

0.17 \(\pm \hspace{0.17em}\)0.13

0.02 \(\pm \hspace{0.17em}\)0.02

1.54 \(\pm \hspace{0.17em}\)0.57

2.50 \(\pm \hspace{0.17em}\)1.42

Salivary glands 2T

0.26 \(\pm \hspace{0.17em}\)0.08

0.75 \(\pm \hspace{0.17em}\)0.31

0.19 \(\pm \hspace{0.17em}\)0.04

0.02 \(\pm \hspace{0.17em}\)0.01

5.41 \(\pm \hspace{0.17em}\)1.93

3.94 \(\pm \hspace{0.17em}\)1.77

Red marrow 2T

0.12 \(\pm \hspace{0.17em}\)0.08

0.67 \(\pm \hspace{0.17em}\)0.37

0.20 \(\pm \hspace{0.17em}\)0.09

0.02 \(\pm \hspace{0.17em}\)0.004

2.43 \(\pm \hspace{0.17em}\)0.84

1.86 \(\pm \hspace{0.17em}\)0.67

Pancreas 2T

0.20 \(\pm \hspace{0.17em}\)0.08

0.58 \(\pm \hspace{0.17em}\)0.36

0.15 \(\pm \hspace{0.17em}\)0.10

0.02 \(\pm \hspace{0.17em}\)0.00

4.52 \(\pm \hspace{0.17em}\)2.30

4.42 \(\pm 2.\) 77

Brain 1T

0.01 \(\pm \hspace{0.17em}\)0.001

0.01 \(\pm \hspace{0.17em}\)0.01

   

4.65 \(\pm \hspace{0.17em}\)7.25

Brain (10min)

    

0.98 \(\pm \hspace{0.17em}\)0.12

 
  1. The Patlak analysis of brain kinetics only included the first 10 min of the scan. Values are presented as mean \(\pm\) SD
  2. 1 T = 1-tissue-compartment model; 2 T = 2-tissue-compartment model; Vt = total distribution volume. Ki = K1*k3/(k2 + k3)