Table 2 Radiation dosimetry of [11C]OHB. Absorbed dose estimates and effective doses in humans
Target organ | Intravenous (\(\upmu\)Sv/MBq) | Oral (\(\upmu\)Sv/MBq) |
|---|---|---|
Adrenals | 4.03 \(\pm \hspace{0.17em}\)0.24 | 5.41 \(\pm \hspace{0.17em}\)1.13 |
Brain | 2.21 \(\pm \hspace{0.17em}\)0.17 | 1.82 \(\pm \hspace{0.17em}\)0.41 |
Breasts | 2.94 \(\pm \hspace{0.17em}\)0.03 | 2.32 \(\pm \hspace{0.17em}\)0.22 |
Esophagus | 3.21 \(\pm \hspace{0.17em}\)0.04 | 3.95 \(\pm \hspace{0.17em}\)0.69 |
Eyes | 2.73 \(\pm \hspace{0.17em}\)0.02 | 1.82 \(\pm \hspace{0.17em}\)0.40 |
Gallbladder wall | 3.54 \(\pm \hspace{0.17em}\)0.08 | 3.71 \(\pm \hspace{0.17em}\)0.22 |
Left colon | 3.68 \(\pm \hspace{0.17em}\)0.03 | 5.40 \(\pm \hspace{0.17em}\)0.57 |
Small intestine | 3.50 \(\pm \hspace{0.17em}\)0.03 | 28.47 \(\pm \hspace{0.17em}\)9.54 |
Stomach wall | 3.63 \(\pm \hspace{0.17em}\)0.07 | 77.70 \(\pm \hspace{0.17em}\)47.19 |
Right colon | 3.54 \(\pm \hspace{0.17em}\)0.02 | 3.32 \(\pm \hspace{0.17em}\)0.53 |
Rectum | 3.49 \(\pm \hspace{0.17em}\)0.05 | 2.86 \(\pm \hspace{0.17em}\)0.54 |
Heart wall | 8.11 \(\pm \hspace{0.17em}\)1.66 | 6.38 \(\pm \hspace{0.17em}\)1.36 |
Kidneys | 6.45 \(\pm \hspace{0.17em}\)0.99 | 4.68 \(\pm \hspace{0.17em}\)0.60 |
Liver | 3.29 \(\pm \hspace{0.17em}\)0.68 | 3.69 \(\pm \hspace{0.17em}\)0.68 |
Lungs | 3.18 \(\pm \hspace{0.17em}\)0.02 | 3.21 \(\pm \hspace{0.17em}\)0.26 |
Ovaries | 3.89 \(\pm \hspace{0.17em}\)0.05 | 3.40 \(\pm \hspace{0.17em}\)0.61 |
Pancreas | 8.22 \(\pm \hspace{0.17em}\)2.14 | 9.15 \(\pm \hspace{0.17em}\)2.95 |
Prostate | 3.09 \(\pm \hspace{0.17em}\)0.04 | 2.42 \(\pm \hspace{0.17em}\)0.44 |
Salivary glands | 5.91 \(\pm \hspace{0.17em}\)2.26 | 2.25 \(\pm \hspace{0.17em}\)0.92 |
Red marrow | 4.23 \(\pm \hspace{0.17em}\)0.43 | 2.42 \(\pm \hspace{0.17em}\)0.17 |
Osteogenic cells | 3.10 \(\pm \hspace{0.17em}\)0.24 | 1.87 \(\pm \hspace{0.17em}\)0.18 |
Spleen | 7.75 \(\pm \hspace{0.17em}\)3.06 | 6.39 \(\pm \hspace{0.17em}\)1.99 |
Testes | 2.67 \(\pm \hspace{0.17em}\)0.04 | 1.78 \(\pm \hspace{0.17em}\)0.40 |
Thymus | 3.35 \(\pm \hspace{0.17em}\)0.05 | 2.62 \(\pm \hspace{0.17em}\)0.21 |
Thyroid | 3.04 \(\pm \hspace{0.17em}\)0.03 | 2.16 \(\pm \hspace{0.17em}\)0.34 |
Urinary bladder wall | 3.47 \(\pm \hspace{0.17em}\)0.53 | 2.52 \(\pm \hspace{0.17em}\)0.56 |
Uterus | 3.83 \(\pm \hspace{0.17em}\)0.05 | 3.59 \(\pm \hspace{0.17em}\)0.68 |
Total body | 3.18 \(\pm \hspace{0.17em}\)0.00 | 3.13 \(\pm \hspace{0.17em}\)0.03 |
Effective dose | 3.28 \(\pm \hspace{0.17em}\)0.09 | 12.51 \(\pm \hspace{0.17em}\)5.90 |