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EJNMMI Radiopharmacy and Chemistry

Table 3 RCY, RCP and stability studies of [177Lu]Lu-DOTA-JR11 in PBS and mouse serum

From: First preclinical evaluation of [225Ac]Ac-DOTA-JR11 and comparison with [177Lu]Lu-DOTA-JR11, alpha versus beta radionuclide therapy of NETs

 

RCY (%)

RCP (%)

PBS (%)*

Mouse serum (%)*

2 h

24 h

2 h

24 h

[177Lu]Lu-DOTA-JR11

99.0

96.6

96.5

96.8

94.5

93.7

  1. *Results are expressed as percentage (%) of intact radiolabeled peptide after incubation at 37 °C (n = 1)
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