Table 5 Comparison of reaction conditions of Charité (synthesis no.3) with Eryilmaz et al.
From: Optimization of 177Lu-labelling of DOTA-TOC, PSMA-I&T and FAPI-46 for clinical application
Charité | Eryilmaz et al. (2021) | |
|---|---|---|
Reaction temperature (°C) | 95 | 90 |
Reaction time (min) | 30 | 20 |
RCY (%) | 95 | 86 |
RCP (%) radio-HPLC | 99.8 | > 99 |
RCP (%) TLC | 100.0 | 98.4 |
Amount of FAPI-46 (µg/GBq) | 9.7 | 27 |