Fig. 3

PET/CT imaging using [⁶⁸Ga]Ga-NOTA-anti-CD70 VHH fragment—A Representative coronal µPET/CT images (30–60 min post injection timeframe summed activity, slice thickness 0.78 mm) of mice bearing CD70^high (786-O (left panel) and with block (middle panel)) and CD70^low tumors (NCl-H1975, right panel). B Time-activity curves for radiotracer distribution in the tumors are shown. (%ID/mL = % injected dose/ mL, injected radiotracer dose = 4–6.7 µg; ~ 6.4–7.4 MBq/mouse; n = 7, data are presented as mean ± SEM. ****p < 0.0001; ^####p = 0.0029)