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EJNMMI Radiopharmacy and Chemistry
Fig. 3 | EJNMMI Radiopharmacy and Chemistry

Fig. 3

From: Radiosynthesis and preclinical evaluation of [11C]SNX-ab as an Hsp90α,β isoform-selective PET probe for in vivo brain and tumour imaging

Fig. 3

In vitro autoradiography. Slices were incubated with [11C]SNX-ab (74 kBq/mL). Binding specificity was assessed by pre-incubation with homologous (SNX-ab) and heterologous (Onalespib, PU-H71, SNX-0723) inhibitors. a Mouse brain slices (n = 3), blocking concentrations of 100 µM. b U87 slices (n = 3), blocking concentrations of 100 µM. c B16.F10 melanoma slices (n = 4), blocking concentrations of 10 µM. Intensity is depicted as DLU/mm2. Blocking% was calculated as (1 − (average DLU/mm2 in tissue slice in the presence of blocking agent))/(average DLU/mm2 in tissue slice tracer only)*100%. Data are presented as mean ± SD. NP Not performed

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