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EJNMMI Radiopharmacy and Chemistry

Table 3 Downscaled reaction conditions, optimized for clinical use

From: Radiolabeling and quality control of therapeutic radiopharmaceuticals: optimization, clinical implementation and comparison of radio-TLC/HPLC analysis, demonstrated by [177Lu]Lu-PSMA

Conditions

Dilution

Gentisic acid (mM)

Ascorbate (mM)

Ethanol % (v/v)

1

80 × 

1.0

4.0

–

2

70 × 

1.2

4.5

10

3

40 × 

2.0

7.9

10

4

15 × 

5.4

21.2

10

5*

–

9.0

35.4

10

  1. *Final volume for condition 1–4 = 50 μL, condition 5 = 30 μL
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