Skip to main content
EJNMMI Radiopharmacy and Chemistry

Table 2 Experimental rotatable central composite design (RCCD) matrix levels selected for temperature and time

From: A closer look at the synthesis of 2-[18F]fluoroethyl tosylate to minimize the formation of volatile side-products

Level

Temperature (°C)

Time (min)

− 1

70

3

 + 1

130

15

− α

79

5

 + α

121

13

0

100

9

X

100

10

  1.  ± 1 minimum and maximum levels
  2.  ± α star points in an axial distance of 1.42
  3. 0 center point
  4. X additional point
Back to article page