Automated synthesis of [68Ga]Ga-FAPI-46 without pre-purification of the generator eluate on three common synthesis modules and two generator types

EJNMMI Radiopharmacy and Chemistry

Table 2 Radiochemical purity and yield of [⁶⁸Ga]Ga-FAPI-46

Modules	Generator	Buffer	Radio chemical purity	Radio chemical yield
Trasis	GalliaPharm	Acetate	93.4%	84%
Scintomics	iThemba	HEPES	90.9%	82%
Synthra	GalliaPharm	HEPES	93.2%	84%

Legend: Syntheses conducted using the cassette and chemistry kit for labeling PSMA-11 with ⁶⁸ Ga at 95 °C for 10 min (n = 3).