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EJNMMI Radiopharmacy and Chemistry

Table 1 Partition coefficient of [18F]FBNA. Compared with [18F]FAZA and [18F]FMISO

From: Synthesis of a 2-nitroimidazole derivative N-(4-[18F]fluorobenzyl)-2-(2-nitro-1H-imidazol-1-yl)-acetamide ([18 F]FBNA) as PET radiotracer for imaging tumor hypoxia

Radiotracer

Partition coefficient (P)

Partition coefficient (log P)

[18F]FBNA

11.21 ± 0.10

1.05 ± 0.04

[18F]FAZA

0.37 ± 0.08

 − 0.43 ± 0.03

[18F]FMISO

2.29 ± 0.12

0.36 ± 0.03

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