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EJNMMI Radiopharmacy and Chemistry
Fig. 3 | EJNMMI Radiopharmacy and Chemistry

Fig. 3

From: Development of a multi faceted platform containing a tetrazine, fluorophore and chelator: synthesis, characterization, radiolabeling, and immuno-SPECT imaging

Fig. 3

In vivo SPECT/CT imaging and biodistribution of [111In]In-DO3A-BODIPY-Tz-TCO-trastuzumab in SKOV-3 (HER2 +) tumors bearing nude mice. (A) SPECT/CT images in %ID/g are shown for 1, 3 and 6 days post-injection (26.7 µg, 4.2 MBq). The tumor is shown by the orange arrow, l: liver and s: spleen. (B) Biodistribution data are presented as mean ± SD of %ID/g for the main organs of interest and the SKOV-3 tumor (26.3 ± 0.3 μg, 4.1 ± 0.1 MBq, n = 4). (C) At 6 days post-injection, half of the tumor was frozen and sectioned for autoradiography. A representative image is shown for the 111In signal (left panel) and the consecutive H&E stained section (right panel)

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