Scheme 1From: A proof-of-concept study on the use of a fluorescein-based 18F-tracer for pretargeted PETSynthesis of the TPF reference compound, employing CuAAC as the key labelling step. a 4-pentynoic acid, oxalyl chloride, DMAP, NEt3, DCM, rt, overnight (62%). b NaOH in MeOH, rt, 2 h (82%). c 1-azido-2-(2-(2-fluoroethoxy)ethoxy)ethane (3), CuSO4.5H2O, sodium ascorbate, TBTA, DMSO, 75 °C, 1 h (64%)Back to article page