EJNMMI Radiopharmacy and Chemistry

Table 1 Uptake experiments of ¹⁸F-labeled FAPI-derivatives with HT1080-FAP and control cell lines

From: ¹⁸F-labeled tracers targeting fibroblast activation protein

FAPI-	10 min	60 min	120 min	CD26	WT	EC50 [nm]
42	40.0 ± 1.73	61.2 ± 1.76	58.0 ± 2.24	n.d	n.d	3.3
52	32.0 ± 0.28	45.9 ± 0.54	53.2 ± 1.38	n.d	n.d	3.2
72	13.9 ± 0.60	23.6 ± 0.40	24.4 ± 0.30^a	n.d	n.d	< 1^b
73	22.7 ± 0.24	39.2 ± 0.48	39.6 ± 0.95^a	n.d	n.d	< 1^b
74	27.2 ± 0.88	29.7 ± 0.66	30.39 ± 2.47	0.18 ± 0.04	0.07 ± 0.03	4.2
75	34.9 ± 0.26	74.0 ± 2.07	82.35 ± 3.61	0.18 ± 0.02	0.06 ± 0.01	3.1
76	45.1 ± 2.20	74.9 ± 0.82	73.05 ± 0.99	n.d	n.d	1.6

All values except EC₅₀ values are given in percent of applied dose on 1 million cells (%AD/10⁶ cells) with standard deviations. ^aMeasurement at 90 min. ^bOut of confidence range

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