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Table 1 Uptake experiments of 18F-labeled FAPI-derivatives with HT1080-FAP and control cell lines

From: 18F-labeled tracers targeting fibroblast activation protein

FAPI- 10 min 60 min 120 min CD26 WT EC50 [nm]
42 40.0 ± 1.73 61.2 ± 1.76 58.0 ± 2.24 n.d n.d 3.3
52 32.0 ± 0.28 45.9 ± 0.54 53.2 ± 1.38 n.d n.d 3.2
72 13.9 ± 0.60 23.6 ± 0.40 24.4 ± 0.30a n.d n.d < 1b
73 22.7 ± 0.24 39.2 ± 0.48 39.6 ± 0.95a n.d n.d < 1b
74 27.2 ± 0.88 29.7 ± 0.66 30.39 ± 2.47 0.18 ± 0.04 0.07 ± 0.03 4.2
75 34.9 ± 0.26 74.0 ± 2.07 82.35 ± 3.61 0.18 ± 0.02 0.06 ± 0.01 3.1
76 45.1 ± 2.20 74.9 ± 0.82 73.05 ± 0.99 n.d n.d 1.6
  1. All values except EC50 values are given in percent of applied dose on 1 million cells (%AD/106 cells) with standard deviations. aMeasurement at 90 min. bOut of confidence range