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EJNMMI Radiopharmacy and Chemistry

Table 3 Stability of [18F]AlF-FAPI-74 for each formulation solution

From: One-pot and one-step automated radio-synthesis of [18F]AlF-FAPI-74 using a multi purpose synthesizer: a proof-of-concept experiment

Formulation solution Elapsed time after synthesis (hr)
Batch 0 (EOS) 2 3 4
Radiochemical purity (%)
Saline     
No. 1 98 96 79 54
No. 2 97 96 94 89
Saline containing 10 mg ascorbic acid and 90 mg sodium ascorbate (pH 5.0) 98 97 96 95
Saline containing 100 mg sodium ascorbate 98 97 97 96
Commercially available phosphate buffered saline (pH 7.4) 98 96 96 95
10 mM phosphate buffered saline (pH 6.7) 98 96 95 89
Commercially available phosphate buffered saline (pH 7.4) containing 100 mg sodium ascorbate 98 97 97 97
10 mM phosphate buffered saline (pH 6.7) containing 100 mg sodium ascorbate     
No. 1 98 97 97 97
No. 2 98 97 97 97
No. 3 98 97 97 97
  1. EOS, end of synthesis
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