Table 1 Results of the optimisation study with tosylate DPA-714 precursor in anhydrous acetonitrile at 90∘C after 10 min with different PTC/base systems. Each run was performed with the indicated volume of the PTC/base combination dissolved in acetonitrile/water 70/30 v/v% for Entry 1 and 85/15 v/v% for Entries 2 and 3
From: Optimised GMP-compliant production of [18F]DPA-714 on the Trasis AllinOne module
PTC | Base | Elution volume [mL] | Radiochemical yield [%]* | [18F]fluoride [%]a |
|---|---|---|---|---|
K222 (37.2 mM) | K2CO3 (11.0 mM) | 1 | 77 | 23 |
K222 (30.0 mM) | KHCO3 (30.0 mM) | 0.75 | 84 | 15 |
TEAB (40.0 mM) | - | 0.6 | 94 | 5 |