Automated synthesis of [18F]Ga-rhPSMA-7/ -7.3: results, quality control and experience from more than 200 routine productions

EJNMMI Radiopharmacy and Chemistry

Table 1 Description of the 9-step fully automated GMP production of [¹⁸F]Ga-rhPSMA-7/ -7.3

Step	Function / Subprocesses	duration
1	Solid phase extraction of [¹⁸F]Fluoride on QMA cartridge	1.0 min
2	Drying of QMA/[¹⁸F]Fluoride	1.5 min
3	Elution of [¹⁸F]Fluoride by [K⁺ ⊂ 2.2.2]OH⁻ in MeCN	0.5 min
4	isotopic exchange reaction on Ga-rhPSMA-7/ -7.3	5.0 min
5	Dilution with buffer	0.5 min
6	Extraction of precursor and product on HLB cartridge	1.0 min
7	Washing of HLB cartridge with buffer	2.0 min
8	Elution of precursor/product from HLB cartridge into product vial	0.5 min
9	Dilution of product solution with buffer	2.0 min
–	Sum of various intermediate steps	1.75 min
1–9		15.75 min