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Table 1 Description of the 9-step fully automated GMP production of [18F]Ga-rhPSMA-7/ -7.3

From: Automated synthesis of [18F]Ga-rhPSMA-7/ -7.3: results, quality control and experience from more than 200 routine productions

Step Function / Subprocesses duration
1 Solid phase extraction of [18F]Fluoride on QMA cartridge 1.0 min
2 Drying of QMA/[18F]Fluoride 1.5 min
3 Elution of [18F]Fluoride by [K+ 2.2.2]OH in MeCN 0.5 min
4 isotopic exchange reaction on Ga-rhPSMA-7/ -7.3 5.0 min
5 Dilution with buffer 0.5 min
6 Extraction of precursor and product on HLB cartridge 1.0 min
7 Washing of HLB cartridge with buffer 2.0 min
8 Elution of precursor/product from HLB cartridge into product vial 0.5 min
9 Dilution of product solution with buffer 2.0 min
Sum of various intermediate steps 1.75 min
1–9   15.75 min