Fig. 3

Optimization summary of fluorination step. For all reactions, [¹⁸F]Fluoride (aq) was evaporated to dryness with 4.5 μL of base and phase-transfer catalyst in DI H₂O, then reacted with 20 μL precursor in DMSO for 5 min. The resulting product was analyzed via radio-TLC. a Effect of temperature on reaction performance; b Effect of base amount on the reaction (K₂₂₂ amount is 1.4x that of K₂CO₃); c Effect of precursor concentration on the reaction. Data points represent the average of n = 4 repeat measurements, and error bars represent standard deviations. In each panel, the changing variable is listed with an “X” (above the graphs), and the fixed values of all other parameters are as indicated. The legend from A applies to all panels