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EJNMMI Radiopharmacy and Chemistry

Table 1 Doses in the Nucleus of a PANC-1 Cell Deposited by RICsa

From: Radioimmunotherapy of PANC-1 human pancreatic cancer xenografts in NOD/SCID or NRG mice with Panitumumab labeled with Auger electron emitting, 111In or β-particle emitting, 177Lu

Source Compartment

S-Value (111In)

(Gy/(Bq × sec)

Panitumumab-DOTA-[111In]In

Panitumumab-MCP-[111In]In

S-Value (177Lu)

(Gy/(Bq × sec)

Panitumumab-DOTA-[177Lu]Lu

  

Ãs (Bq × sec)

Dose (Gy)

Ãs (Bq × sec)

Dose (Gy)

 

Ãs (Bq × sec)

Dose (Gy)

CS

7.35 × 10−5

9.24 × 103

0.68

2.67 × 103

0.20

3.55 × 10− 4

9.77 × 103

3.47

Cy

1.03 × 10− 4

1.01 × 103

0.10

1.16 × 103

0.12

4.02 × 10− 4

1.07 × 103

0.43

N

5.06 × 10− 4

0.67 × 103

0.34

0.40 × 103

0.20

6.93 × 10− 4

0.70 × 103

0.49

Total Ãs (cell; Bq × sec)

 

10.92 × 103

 

4.23 × 103

  

11.54 × 103

 

Medium

1.50 × 10−12

5.91 × 1010

0.09

6.19 × 1010

0.09

4.72 × 10− 12

6.20 × 1010

0.29

Total dose (cell and medium)

  

1.21

 

0.61

  

4.68

Major Contributor

  

CS (56%)

 

CS/N

(30%)

  

CS

(74%)

  1. a2 × 105 PANC-1 cells were incubated with 1.2 MBq (2.5 nmoles/L) of RICs in 2.0 mL of growth medium for 16 h at 37 °C, then seeded and cultured for 10 days
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