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Table 1 Doses in the Nucleus of a PANC-1 Cell Deposited by RICsa

From: Radioimmunotherapy of PANC-1 human pancreatic cancer xenografts in NOD/SCID or NRG mice with Panitumumab labeled with Auger electron emitting, 111In or β-particle emitting, 177Lu

Source Compartment S-Value (111In)
(Gy/(Bq × sec)
Panitumumab-DOTA-[111In]In Panitumumab-MCP-[111In]In S-Value (177Lu)
(Gy/(Bq × sec)
Panitumumab-DOTA-[177Lu]Lu
   Ãs (Bq × sec) Dose (Gy) Ãs (Bq × sec) Dose (Gy)   Ãs (Bq × sec) Dose (Gy)
CS 7.35 × 10−5 9.24 × 103 0.68 2.67 × 103 0.20 3.55 × 10− 4 9.77 × 103 3.47
Cy 1.03 × 10− 4 1.01 × 103 0.10 1.16 × 103 0.12 4.02 × 10− 4 1.07 × 103 0.43
N 5.06 × 10− 4 0.67 × 103 0.34 0.40 × 103 0.20 6.93 × 10− 4 0.70 × 103 0.49
Total Ãs (cell; Bq × sec)   10.92 × 103   4.23 × 103    11.54 × 103  
Medium 1.50 × 10−12 5.91 × 1010 0.09 6.19 × 1010 0.09 4.72 × 10− 12 6.20 × 1010 0.29
Total dose (cell and medium)    1.21   0.61    4.68
Major Contributor    CS (56%)   CS/N
(30%)
   CS
(74%)
  1. a2 × 105 PANC-1 cells were incubated with 1.2 MBq (2.5 nmoles/L) of RICs in 2.0 mL of growth medium for 16 h at 37 °C, then seeded and cultured for 10 days