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EJNMMI Radiopharmacy and Chemistry
Fig. 2 | EJNMMI Radiopharmacy and Chemistry

Fig. 2

From: Radioimmunotherapy of PANC-1 human pancreatic cancer xenografts in NOD/SCID or NRG mice with Panitumumab labeled with Auger electron emitting, 111In or β-particle emitting, 177Lu

Fig. 2

a Representative immunofluorescence microscopy images of PANC-1 cells exposed to growth medium, unlabeled panitumumab-MCP or panitumumab-DOTA or 1.2 MBq (2.5 nmoles/L) of panitumumab-MCP-[111In]In, panitumumab-DOTA-[111In]In or panitumumab-DOTA-[177Lu]Lu showing γ-H2AX foci in the nucleus, counterstained blue with DAPI. b Integrated density of γ-H2AX foci representing unrepaired DNA DSBs in the nucleus of PANC-1 cells exposed to RICs. Values shown are the mean ± SD (n = 12). Significant differences (P < 0.05) are noted by the asterisks. c Integrated density of γ-H2AX foci in the nucleus of PANC-1 cells exposed to RICs vs. absorbed dose (Gy) in the nucleus. Lines were obtained by linear regression

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