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Fig. 7 | EJNMMI Radiopharmacy and Chemistry

Fig. 7

From: Automated [18F]PSMA-1007 production by a single use cassette-type synthesizer for clinical examination

Fig. 7

Chromatograms of reference standards and [18F]PSMA-1007. a The typical ion-chromatogram of the tetrabutylammonium (TBA) reference standard and [18F]PSMA-1007 solution produced using cassettes with three types of tubing material with the TFA salt precursor. The TBA reference standard was 260 μg/mL (RT 7.363 min). The TBA peak of [18F]PSMA-1007 solution was not detected. The lower limit of the calibration curve was 2.6 μg/mL. b The typical gas-chromatogram of the acetonitrile (MeCN) and DMSO reference standards and [18F]PSMA-1007 solution produced using cassettes with three types of tubing material with the TFA salt precursor. The MeCN and DMSO reference standards were 79 ppm (RT 4.251 min) and 110 ppm (RT 11.966 min), respectively. The MeCN and DMSO peaks of the [18F]PSMA-1007 solution were not detected. The MeCN and DMSO lower limit of the calibration curves were 8 ppm and 11 ppm, respectively. c The typical gas-chromatogram of the ethanol reference standard and [18F]PSMA-1007 solution produced using three types of cassettes with the TFA salt precursor (this chromatogram is a zoom out of Fig. 7b). The ethanol reference standard was 10% v/v (RT 3.357 min). The ethanol peak of the [18F]PSMA-1007 solution was detected at approximately 3.4 min of retention time and the concentration was approximately 8% v/v in all cassettes

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