Table 1 Optimization of the [11C]UCB-J synthesis
From: Improved synthesis of SV2A targeting radiotracer [11C]UCB-J
Method | Reaction steps | [11C] CH3I[GBq]c | Precursor [mg] | Solvent | Reaction temperature | Reaction Time (min) | [11C]UCB-J [MBq]d | RCYe | nf |
|---|---|---|---|---|---|---|---|---|---|
I | 2a | 18 ± 4 | 1.2 ± 0.1 | DMF-H2O (8:1) | 30 °C + 100 °C | 3 + 5 | 53 ± 15 | < 1% | 3 |
I | 2a | 18; 20 | 3.0; 3.0 | DMF-H2O (8:1) | 30 °C + 100 °C | 3 + 5 | 138; 216 | 3%; 4% | 2 |
II | 2a | 21 ± 4 | 1.1 ± 0.1 | THF-H2O (34:4) | 30 °C + 70 °C | 3 + 5 | 890 ± 240 | 16 ± 5% | 7 |
III | 1b | 17 ± 2 | 1.1 ± 0.1 | THF-H2O (35:4) | 70 °C | 4 | 1780 ± 460 | 39 ± 5% | 9 |