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Table 2 Stability data for 68Ga, 44Sc and 177Lu complexes of AAZTA5 and AAZTA5-TOC against human serum, PBS buffer and EDTA and DTPA in PBS buffer in percent of stable complex at specific time points (% labelled compound compared to free activity found at given time point)

From: AAZTA5/AAZTA5-TOC: synthesis and radiochemical evaluation with 68Ga, 44Sc and 177Lu

  68Ga 44Sc 177Lu
time AAZTA5 AAZTA5-TOC time AAZTA5 AAZTA5-TOC time AAZTA5 AAZTA5-TOC
HS 30 min 93.0 ± 0.8 98.1 ± 0.2 1 h 93.7 ± 0.9 95.1 ± 0.6 1 h 99.8 ± 0.1 92.5 ± 1.9
1 h 92.7 ± 1.3 96.9 ± 0.2 4 h 94.3 ± 1.7 94.3 ± 0.8 2 h 99.7 ± 0.1 92.3 ± 2.6
2 h 85.3 ± 3.4 95.0 ± 0.3 8 h 93.2 ± 1.1 95.0 ± 1.1 24 h 99.9 ± 0.1 91.5 ± 2.1
    24 h 91.3 ± 1.8 93.8 ± 1.0 7 d 82.5 ± 3.2 86.3 ± 3.2
PBS 30 min 97.5 ± 1.0 99.1 ± 0.2 1 h 95.3 ± 0.9 97.3 ± 0.5 1 h 97.8 ± 0.5 92.0 ± 1.4
1 h 88.7 ± 0.5 99.2 ± 0.1 4 h 92.7 ± 1.3 98.5 ± 0.9 2 h 98.6 ± 0.4 93.5 ± 1.3
2 h 78.5 ± 4.5 99.3 ± 0.1 8 h 95.9 ± 1.2 96.7 ± 1.4 24 h 99.1 ± 0.6 91.0 ± 2.2
    24 h 96.0 ± 0.8 94.7 ± 1.6 7 d 96.0 ± 0.8 93.1 ± 1.8
EDTA 30 min 93.0 ± 0.2 98.9 ± 0.4 1 h 93.7 ± 1.3 96.0 ± 0.4 1 h 98.9 ± 0.2 95.7 ± 2.4
1 h 50.3 ± 7.4 99.4 ± 0.2 4 h 90.0 ± 3.2 97.6 ± 0.7 2 h 97.9 ± 0.3 95.1 ± 2.6
2 h 49.5 ± 2.5 99.6 ± 0.1 8 h 92.3 ± 2.1 96.9 ± 1.0 24 h 79.2 ± 2.9 86.8 ± 2.6
    24 h 91.9 ± 1.8 95.4 ± 2.1 7 d 48.9 ± 1.5 77.5 ± 2.3
DTPA 30 min 84.3 ± 0.9 97.8 ± 0.2 1 h 94.3 ± 0.9 98.7 ± 0.3 1 h 99.1 ± 0.2 98.9 ± 0.5
1 h 78.0 ± 1.4 99.4 ± 0.1 4 h 92.5 ± 0.5 98.9 ± 0.7 2 h 99.1 ± 0.1 96.2 ± 3.2
2 h 45.7 ± 1.3 99.6 ± 0.3 8 h 93.8 ± 1.2 96.9 ± 1.5 24 h 80.4 ± 5.4 82.8 ± 4.7
    24 h 93.4 ± 1.1 92.6 ± 3.2 7 d 59.0 ± 14.3 72.9 ± 5.6