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Table 1 Biodistribution of radioactivity in mice after the injection with [11C]1 or [11C]2

From: Radiosynthesis and in vivo evaluation of 11C-labeled BMS-193885 and its desmethyl analog as PET tracers for neuropeptide Y1 receptors

Tissue Radioactivity level (%ID/g)a
5 minb 15 minb 30 minb 60 minb
[11C]1 [11C]2 [11C]1 [11C]2 [11C]1 [11C]2 [11C]1 [11C]2
Blood 0.76±0.07 0.65±0.05 0.60±0.06 0.21±0.01 0.50±0.04 0.17±0.02 0.46±0.06 0.19±0.20
Heart 1.93±0.23 0.69±0.09 1.38±0.04 0.42±0.02 1.10±0.05 0.28±0.04 0.82±0.07 0.14±0.04
Lung 5.08±1.12 1.00±0.08 3.43±0.28 0.79±0.11 2.72±0.21 0.82±0.13 2.13±0.36 0.65±0.08
Liver 16.09±1.85 29.54±1.57 8.82±2.28 24.28±3.04 5.05±0.40 15.54±4.41 4.09±1.60 8.43±2.71
Pancreas 3.40±0.46 1.20±0.18 3.75±0.35 1.27±0.11 3.64±0.22 1.18±0.18 3.70±0.41 1.15±0.13
Spleen 3.18±0.67 0.79±0.11 2.05±0.17 0.55±0.07 1.66±0.04 0.37±0.07 1.41±0.24 0.23±0.05
Kidney 17.41±1.12 13.25±1.18 14.06±1.00 10.96±0.51 12.93±1.01 9.89±0.52 13.37±2.72 9.23±1.61
Small intestine 6.98±2.37 15.78±6.51 9.11±1.31 30.77±8.94 11.02±1.44 27.23±12.69 12.43±1.54 13.52±4.25
Muscle 0.64±0.05 0.44±0.21 0.57±0.08 0.30±0.02 0.52±0.11 0.38±0.17 0.47±0.07 0.33±0.19
Brain 0.21±0.01 0.05±0.02 0.40±0.06 0.04±0.04 0.32±0.05 0.01±0.00 0.32±0.05 0.03±0.01
  1. aMean±S.D. (n=4)
  2. bTime elapsed after the injection of 11C-labeled tracer