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Table 1 Quality control (QC) conditions reported in the literature and in the EP for the synthesis of [11C]MET with ultraviolet (UV) detection

From: An alternative methodology for the determination of the radiochemical purity of 11C-methionine

Author/ year Column Eluent Flow (mL/min) Run time (min) Homocys-teine (tr in min) Homocys-teine thiolactone (tr in min) Methi-onine (tr in min)
EP (Council of Europe, 2014) C18 (250 × 4.6 mm, 5 μm) KH2PO4 1.4 g/L 1.0 10 2.1 7.0 2.6
A.Bogni et al., 2003 (Bogni et al., 2003) YMC-Pack pro C18 (4.6 × 250 mm 5 μm) NaH2PO4 0.05 M 1.2 nr nr nr nr
Mitterhauser et al., 2005 (Mitterhauser et al., 2005) Phenosphere 10 μm ODS(1) KH2PO4 1.4 g/L 1–4 min:1.0; 4–15 min: 3.0 nr 4.5 nr 5.2
G. Quinoces et al., 2006 (Quincoces et al., 2006) Supelcosil C18 (250 × 4.6 mm, 10 μm) KH2PO4 0.01 M 1.0 nr nr nr 3.0
F. Lodi et al., 2007 (Lodi et al., 2007) Nucleosil 100–3 C18 (3 × 250 mm) M-N NaH2PO4 0.05 M:EtOH (98:2) 0.3 nr 4.5 4.3 5.5
V. Gómez et al., 2008 (Gómez et al., 2008) Zorbax eclipse SB-Aq C18 (4.6 × 250 mm, 5 μm) KH2PO4 1.4 g/L 1.0 13 nr nr 4.12
F. Lodi, et al., 2008 (Lodi et al., 2008) Nucleosil 100–3 C18 (3 × 250 mm) M-N NaH2PO4 0.05 M:EtOH (98:2) 0.3 nr 4.5 4.3 5.5
N. Gozmina, et al., 2011 (Gomzina & Kuznetsova, 2011) Zorbax SCX (250 × 4.6 mm) NaH2PO4 0.01 M pH = 3 1.0 nr 4.12 20.1 5.93
C. Pascali et al., 2011 (Pascali et al., 2011) μBondapack C18 (300 × 3.9 mm, 10 μm) NaH2PO4 0.003 M pH = 3.1 1.0 nr 3.34 3.70 3.80
YMC-Pack Pro C18 (250 × 4.6 mm, 5 μm) KH2PO4 0.05 M 1.0 nr 4.05 4.12 5.5
YMC-Pack Pro C18 (250 × 4.6 mm, 5 μm) KH2PO4 0.01 M 1.0 nr 3.94 3.68 5.55
Spherisorb ODS1 (250 × 4.6 mm, 5 μm) KH2PO4 0.01 M 1.0 nr 3.39 10.78 4.31
  1. nr not reported