Synthesis and preliminary preclinical evaluation of fluorine-18 labelled isatin-4-(4-methoxyphenyl)-3-thiosemicarbazone ([18F]4FIMPTC) as a novel PET tracer of P-glycoprotein expression

EJNMMI Radiopharmacy and Chemistry

Table 2 Stability of [¹⁸F]5 assessed in several formulation solutions; N = 2 for each time point

Time (Minutes)	5	15	30	45	60	90
10% ethanol in saline	92	–	–	–	76	69
DMSO	89	85	–	–	72	–
Ethanol	97	80	–	67	–	–
Free radical scavengers	95	–	89	–	79	–
acetonitrile	96	–	96	–	96	–
20% Tween-80 in saline	95	95	–	95	–	–
2.5% Tween-80 in saline	95	94	94	94	94	–