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Table 3 Biodistibution of 68Ga-NODAGA-JR11, 68Ga-DOTATOC and 68Ga-DOTATATE in NOD scid gamma ZR-75-1 tumor-bearing mice

From: Evaluation of agonist and antagonist radioligands for somatostatin receptor imaging of breast cancer using positron emission tomography

  68Ga-NODAGA-JR11
n = 5
68Ga-DOTATOC
n = 6
68Ga-DOTATATE
n = 6
  Mean SD Mean SD Mean SD
Tumor 12.21 0.78 18.44 2.87 *** 15.22 2.20
Blood 0.80 0.10 0.45 0.09 *** 0.35 0.06 ***
Fat 0.23 0.11 0.18 0.09 0.28 0.15
Ovaries 0.67 0.22 0.51 0.07 0.89 0.35
Uterus 0.86 0.22 0.54 0.11 0.84 0.10
Intestines 0.90 0.20 2.39 0.30 *** 7.35 0.44 ***
Stomach 1.36 0.78 2.75 1.25 8.29 3.06 ***
Pancreas 9.29 2.03 11.01 1.32 51.56 5.47 ***
Spleen 0.39 0.05 0.46 0.11 0.84 0.38
Kidneys 14.12 1.65 9.27 1.73 *** 8.45 1.73 ***
Adrenals 2.00 0.65 9.52 3.78 ** 15.20 7.26 **
Liver 0.99 0.12 0.71 0.17 1.95 0.52 ***
Lungs 4.72 0.71 22.93 6.12 *** 28.66 2.94 ***
Heart 0.46 0.06 0.30 0.04 * 0.67 0.13 **
Muscle 0.28 0.07 0.11 0.02 *** 0.11 0.04 ***
Bone 0.26 0.04 0.20 0.03 0.25 0.03
Brain 0.05 0.02 0.03 0.01 0.03 0.01
Tumor to Background Ratios
Blood 15.56 2.20 41.13 5.68 *** 44.65 11.74 ***
Muscle 45.15 11.56 171.51 55.33 ** 151.95 60.75 **
Kidneys 0.87 0.12 2.01 0.24 *** 1.88 0.48 ***
  1. Organ uptake is expressed as mean ± standard deviation (SD) in units of percent injected dose per gram of tissue (%ID/g). The tumor uptake is highlighted in bold. Means were statistically compared to the respective organ uptake of 68Ga-NODAGA-JR11 and p values < 0.05, < 0.01, and < 0.001 were expressed as *, ** and *** respectively