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EJNMMI Radiopharmacy and Chemistry

Table 3 Biodistibution of 68Ga-NODAGA-JR11, 68Ga-DOTATOC and 68Ga-DOTATATE in NOD scid gamma ZR-75-1 tumor-bearing mice

From: Evaluation of agonist and antagonist radioligands for somatostatin receptor imaging of breast cancer using positron emission tomography

 

68Ga-NODAGA-JR11

n = 5

68Ga-DOTATOC

n = 6

68Ga-DOTATATE

n = 6

 

Mean

SD

Mean

SD

Mean

SD

Tumor

12.21

0.78

18.44

2.87 ***

15.22

2.20

Blood

0.80

0.10

0.45

0.09 ***

0.35

0.06 ***

Fat

0.23

0.11

0.18

0.09

0.28

0.15

Ovaries

0.67

0.22

0.51

0.07

0.89

0.35

Uterus

0.86

0.22

0.54

0.11

0.84

0.10

Intestines

0.90

0.20

2.39

0.30 ***

7.35

0.44 ***

Stomach

1.36

0.78

2.75

1.25

8.29

3.06 ***

Pancreas

9.29

2.03

11.01

1.32

51.56

5.47 ***

Spleen

0.39

0.05

0.46

0.11

0.84

0.38

Kidneys

14.12

1.65

9.27

1.73 ***

8.45

1.73 ***

Adrenals

2.00

0.65

9.52

3.78 **

15.20

7.26 **

Liver

0.99

0.12

0.71

0.17

1.95

0.52 ***

Lungs

4.72

0.71

22.93

6.12 ***

28.66

2.94 ***

Heart

0.46

0.06

0.30

0.04 *

0.67

0.13 **

Muscle

0.28

0.07

0.11

0.02 ***

0.11

0.04 ***

Bone

0.26

0.04

0.20

0.03

0.25

0.03

Brain

0.05

0.02

0.03

0.01

0.03

0.01

Tumor to Background Ratios

Blood

15.56

2.20

41.13

5.68 ***

44.65

11.74 ***

Muscle

45.15

11.56

171.51

55.33 **

151.95

60.75 **

Kidneys

0.87

0.12

2.01

0.24 ***

1.88

0.48 ***

  1. Organ uptake is expressed as mean ± standard deviation (SD) in units of percent injected dose per gram of tissue (%ID/g). The tumor uptake is highlighted in bold. Means were statistically compared to the respective organ uptake of 68Ga-NODAGA-JR11 and p values < 0.05, < 0.01, and < 0.001 were expressed as *, ** and *** respectively
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