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EJNMMI Radiopharmacy and Chemistry

Table 1 Organ and tissue uptake of 1-TG (a) and 5-TG (b) over time

From: In vivo evaluation of tumor uptake and bio-distribution of 99mTc-labeled 1-thio-β-D-glucose and 5-thio-D-glucose in mice model

(a) 1-TG

 

0.5 h

2 h

4 h

 

Organ

ID%

SD

ID%

SD

ID%

SD

p-value

Blood

2.34

1.14

0.99

0.35

0.51

0.16

0.0006

Brain

0.07

0.04

0.04

0.02

0.02

0.01

0.002

Heart

0.87

0.27

0.52

0.18

0.31

0.11

0.0006

Liver

2.60

2.80

2.34

2.67

1.20

0.73

0.547

Kidney left

10.10

3.03

8.28

4.49

12.18

8.77

0.564

Kidney right

9.82

3.13

8.43

4.58

12.69

8.93

0.547

Spleen

0.93

0.71

0.85

0.86

0.56

0.47

0.329

Stomach

0.29

0.07

0.18

0.10

0.20

0.13

0.080

Bowel

0.67

0.27

0.68

0.44

0.33

0.28

0.040

Lungs

1.44

0.53

0.82

0.25

0.54

0.14

0.001

Muscle

0.46

0.19

0.15

0.03

0.16

0.11

0.001

Tumor

0.82

0.30

0.54

0.18

0.56

0.26

0.1

Tumor-to-muscle-Ratio#

2.06

1.14

3.65

1.18

4.12

2.12

0.001

Tumor (A549)*

0.78

0.36

0.47

0.20

0.52

0.35

0.397

Tumor-to-muscle-Ratio (A549)*

2.25

1.12

3.15

1.12

4.01

1.78

0.210

Tumor (HCT-116)*

0.86

0.27

0.61

0.16

0.60

0.16

0.231

Tumor-to-muscle-Ratio (HCT-116)*

1.87

1.30

4.15

1.15

4.23

2.70

0.167

(b) 5-TG

 

0.5 h

2 h

4 h

 

Organ

ID%

SD

ID%

SD

ID%

SD

p-value

Blood

1.43

1.12

0.70

0.28

0.51

0.23

0.060

Brain

0.11

0.11

0.07

0.05

0.05

0.03

0.505

Heart

0.85

0.43

0.42

0.10

0.29

0.14

0.024

Liver

6.38

2.94

7.37

4.83

5.95

2.63

0.898

Kidney left

4.71

1.97

3.34

1.31

2.25

0.91

0.059

Kidney right

4.81

1.91

3.40

1.33

2.43

0.90

0.046

Spleen

2.90

2.36

3.81

3.17

3.51

2.02

0.796

Stomach

0.46

0.47

0.16

0.10

0.32

0.37

0.394

Bowel

0.64

0.43

0.48

0.48

0.27

0.18

0.172

Lungs

7.24

4.10

3.40

3.01

2.08

1.49

0.032

Muscle

0.46

0.87

0.13

0.05

0.11

0.13

0.119

Tumor

0.37

0.27

0.27

0.07

0.23

0.09

0.505

Tumor-to-muscle-Ratio#

1.92

1.27

2.25

0.73

3.41

1.60

0.134

Tumor (A549)*

0.21

0.18

0.22

0.07

0.20

0.10

0.550

Tumor-to-muscle-Ratio (A549)*

1.67

0.86

2.03

0.71

4.07

1.26

0.023

Tumor (HCT-116)*

0.53

0.25

0.31

0.02

0.27

0.08

0.086

Tumor-to-muscle-Ratio (HCT-116)*

2.16

1.70

2.46

0.78

2.74

1.79

0.981

  1. Bold indicates p < 0.05
  2. n = 8 (A549 plus HCT116) if not indicated otherwise
  3. *n = 4, and ratio instead of ID%/g
  4. #Both cell lines, and ratio instead of ID%. p-values are given for comparison of each time point for each tissue. Only mice with tumor inoculation have been used in this analysis
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