Scheme 1From: Synthesis and evaluation of fluorine-18 labelled tetrazines as pre-targeting imaging agents for PET[18F]Fluoride was trapped on a Chromabond PS-HCO3 cartridge and dried with acetonitrile. a The precursor Py-TFP 3 in acetonitrile was reacted with the [18F]fluoride on the solid support and the formed [18F]F-Py-TFP 4 ester eluted from the cartridge. Unreacted precursor Py-TFP 3 was removed by an Oasis MCX Plus cartridge. b The labelled tetrazines [18F]MeTz 6a and [18F]HTz 6b were synthesized by direct amidationBack to article page