Fig. 3
From: A novel PET probe to selectively image heat shock protein 90α/β isoforms in the brain
PET imaging of [11C]BIIB021 in healthy rats. a Brain PET images of rats injected [11C]BIIB021 with or without nonlabelled BIIB021. Images are averaged from 0 to 120 min after injection. Coronal section images are displayed with color scale units in standardized uptake values overlayed on a template MR image. Left four images are at baseline and right four images are after blocking with 2 mg/kg BIIB021. b Whole brain (left) and regional time-activity curves at the baseline (middle) and block experiments (right). In the left graph, increased washout was observed after blocking with 2 mg/kg BIIB021 (filled circle) compared to at the baseline (open circle). In the middle and right graph, regional differences seen at the baseline (middle) became smaller after the blocking (right). Regions: amygdala (red circle), cerebellum (purple triangle), and thalamus (blue inverted triangle)