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EJNMMI Radiopharmacy and Chemistry
Fig. 2 | EJNMMI Radiopharmacy and Chemistry

Fig. 2

From: A novel PET probe to selectively image heat shock protein 90α/β isoforms in the brain

Fig. 2

Binding of [11C]BIIB021 in rat brain homogenates a and human recombinant HSP90α b and HSP90β proteins c. Total (blue circles) and non-specific (red squares) binding of [11C]BIIB021 to a healthy rat brain homogenate, HSP90α and HSP90β. Homologous blocking was performed by 10 μM of nonlabelled BIIB021. The binding by BIIB021 was described by a 1-site model and fitted curves are indicated

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