Table 1 In vitro data (1saturation binding assay, 2real-time radioligand binding) for the 64Cu-labeled compounds [64Cu]Cu-14–[64Cu]Cu-16 and their respective Log D7.4 values
From: Chelator impact: investigating the pharmacokinetic behavior of copper-64 labeled PD-L1 radioligands
Compound | KD [nM]1 | Bmax [pmol/mg] | KD [nM]2 | ka (M × s)–1 | kd s–1 | Log D7.4 |
|---|---|---|---|---|---|---|
[64Cu]Cu-14 | 100.4 ± 9.23 | 2.40 ± 0.48 | 23.3 ± 1.67 | (5.06 ± 0.25) × 103 | (1.17 ± 0.06) × 10–4 | –3.00 ± 0.03 |
[64Cu]Cu-15 | 184.8 ± 15.4 | 2.58 ± 0.35 | 19.1 ± 1.69 | (5.10 ± 0.55) × 103 | (0.96 ± 0.02) × 10–4 | –2.11 ± 0.02 |
[64Cu]Cu-16 | 265.0 ± 12.5 | 3.30 ± 0.46 | 24.2 ± 0.93 | (5.55 ± 0.31) × 103 | (1.35 ± 0.09) × 10–4 | –2.79 ± 0.02 |