Table 3 General overview and practical considerations for the radiolabelling with Ac-225
Step | Critical handling |
|---|---|
Preparation of the equipment and solutions | Metal free handling |
Measurement of the Ac-225 stock | Validated geometry |
Labelling | Order of addition, never add activity to pharmaceutical before addition of the quencher Excess DTPA after labelling (DOTA-chelate) |
Stabilization | Rapid stabilization with quencher after heating |
Quality control | When the time after separation increases, the accuracy of output increases |
Filtration | Loss of activity |