Fig. 9

Example of a chromatogram generated by plotting Fr-221 counts obtained from samples collected by a fraction collector after HPLC separation (LiChrospher RP-18 endcapped (5 µm)) Merck, Amsterdam, The Netherlands) for [²²⁵Ac]Ac-PSMA-I&T (Eluents A: Water containing 0.1% TFA and 5% acetonitrile, B: acetonitrile containing 0.1% TFA and 5% water), gradient 0–2 min 100% solvent A, 2–10 min to 100% B, 10–15 100% solvent B, 15–20 100% solvent A) (a) and [²²⁵Ac]Ac-DOTA-TATE (Eluents A: 0.1% TFA, B: MeOH, gradient 0–2 min 100% A, 3–20 min 45–40% A, 20–25 min 100% B, 25–30 min 100% A) (b)