Skip to main content
EJNMMI Radiopharmacy and Chemistry
Fig. 2 | EJNMMI Radiopharmacy and Chemistry

Fig. 2

From: A novel PSMA-targeting tracer with highly negatively charged linker demonstrates decreased salivary gland uptake in mice compared to [68Ga]Ga-PSMA-11

Fig. 2

Left panel: [68Ga]Ga-PSMA-11 and [68Ga]Ga-JB-1498 head-to-head comparison micro-PET images at 1 h post injection, with same SUV grayscale. There is very little salivary gland (SG) and background activity in the mouse injected with [68Ga]Ga-JB-1498 compared to [68Ga]Ga-PSMA-11. Most of the injected [68Ga]Ga-JB-1498 is in the urinary bladder due to rapid tracer excretion via the kidneys. Right Panel: representative time-activity curve of [68Ga]Ga-PSMA-11 and [68Ga]Ga-JB-1498 in salivary glands (combined parotid and submandibular glands) and kidneys during the first hour of micro-PET imaging. The diverging time activity curve reflects active salivary gland and renal cortical uptake of [68Ga]Ga-PSMA-11 and lack of specific uptake of [68Ga]Ga-JB-1498 in these two organs

Back to article page