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EJNMMI Radiopharmacy and Chemistry
Fig. 10 | EJNMMI Radiopharmacy and Chemistry

Fig. 10

From: Physiologically based radiopharmacokinetic (PBRPK) modeling to simulate and analyze radiopharmaceutical therapies: studies of non-linearities, multi-bolus injections, and albumin binding

Fig. 10

Dependence of dose on the dissociation constant of the albumin-ligand reaction. With higher albumin affinity (i.e. lower values of the dissociation constant), we observe that the dose to OAR and tumor both start to increase (as one moves to the left of the solid line) which is due to the increased residence time of the radiopharmaceuticals. However, for further lower dissociation value (beyond the dotted-dashed line), the dose to OAR starts decreasing while the dose to tumor still increases, attributed to leakage of albumin and albumin-bound ligands in the interstitial space of the tumor (see discussion). Finally, with much lower values of \(K_D^{alb}\) (beyond the dashed line), all doses decrease related to the fact that with very strong affinities, there will be limited binding to receptors

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