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EJNMMI Radiopharmacy and Chemistry
Fig. 1 | EJNMMI Radiopharmacy and Chemistry

Fig. 1

From: Physiologically based radiopharmacokinetic (PBRPK) modeling to simulate and analyze radiopharmaceutical therapies: studies of non-linearities, multi-bolus injections, and albumin binding

Fig. 1

Dependence of the delivered dose to organs on the injected hot amount and injected cold amount. Moving from the left side of each plot to the right side, we observe that the iso-dose lines get tilted, suggesting more competition between hot and cold species. In addition, the two dots on the 20 Gy iso-dose curve reveal that one can achieve the same absorbed dose in the tumor by lower injected activity if accompanied by lower cold amount (i.e. higher specific activity)

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