Scheme 2
From: Cu(II)-Mediated direct 18F-dehydrofluorination of phosphine oxides in high molar activity
Synthetic routes for phosphine oxides and phosphinic fluorides. a Synthetic route of phosphine oxides 1a and 2a. b Synthetic route of phosphinic fluorides 1–4. c Three synthetic routes of phosphine oxides 4a. DCC: Dicyclohexylcarbodiimide; DMAP: 4-Dimethylaminopyridine. EBMPA: Ethyl 2-bromo-2-methylpropanoate; TBDCP: tert-Butyldichlorophosphane; TFP: 2,3,5,6-Tetrafluorophenol