Fig. 2
From: Cu(II)-Mediated direct 18F-dehydrofluorination of phosphine oxides in high molar activity
Optimization of 18F-fluorination condition for activated ester [18F]4. a The effects of solvent on RCCs; Reaction conditions: precursor 4a (3 μmol), Cu(OAc)2 (2 equiv.), [18F]TBAF (2–3 mCi), solvent (200 μL), 25 °C, 10 min. b The effects of time on RCCs; Reaction conditions: precursor 4a (3 μmol), Cu(OAc)2 (2 equiv.), [18F]TBAF (2–3 mCi), DMF (200 μL), 25 °C, 1–30 min. c The effects of temperature on RCCs; Reaction conditions: precursor 4a (3 μmol), Cu(OAc)2 (2 equiv.), [18F]TBAF (2–3 mCi), DMSO (200 μL), 25–125 °C, 10 min. d The effects of precursor loads on RCCs; Reaction conditions: precursor 4a (0.1–5 μmol), Cu(OAc)2 (2 equiv.), [18F]TBAF (2–3 mCi), DMSO (200 μL), 25 °C, 10 min. e The effects of equivalents of Cu(OAc)2 on RCCs; Reaction conditions: precursor 4a (3 μmol), Cu(OAc)2 (0–4 equiv.), [18F]TBAF (2–3 mCi), DMSO (200 μL), 25 °C, 10 min. f The effects of [18F]F− source on RCCs; Reaction conditions: precursor 4a (3 μmol), Cu(OAc)2 (2 equiv.), [18F]F− source (2–3 mCi), DMSO (200 μL), 25 °C, 10 min. g The effects of equivalents of H2O on RCCs; Reaction conditions: precursor 4a (3 μmol), Cu(OAc)2 (2 equiv.), [18F]TBAF (2–3 mCi), DMSO (200 μL), H2O (10–500 equiv.), 25 °C, 10 min. h Substrate scope for the synthesis of 18F-labeled fluorophosphine. Conditions: precursors (3 μmol), Cu(OAc)2 (2 equiv.), [18F]TBAF (2–3 mCi), DMSO (200 μL), 25 °C, 10 min. i The Am of Cu(II)-mediated dehydrofluorination versus 18F/19F-isotope exchange; Method I: precursor 4a (3 μmol), Cu(OAc)2 (2 equiv.), [18F]TBAF (20 mCi), DMSO (200 μL), 25 °C, 10 min. Method II: precursor 4 (3 μmol), [18F]KF/K222 (20 mCi), CH3CN (200 μL), 25 °C, 10 min