Fig. 5

PET imaging for [¹⁸F]7b in tumor-bearing mice. A PET images at selected time points after intravenous injection of [¹⁸F]7b in mice bearing A375-hS100A4 (upper panel, 8.91 MBq) or MeWo (lower panel, 10.04 MBq) tumors on the right leg. Images are presented as maximum intensity projections and shown at a common scale (SUV 0–3). Indicated time points correspond to the following time frames: 5 min [4–6 min], 30 min [25–30 min], and 1 h [50–60 min]. Anatomical positions of the tumors used for SUV quantification are shown as white circles. Of note, the SUV scale for the images was set from 0.0 to 3.0 in contrast to the scale used for the PET images in Fig. 2A (0.0–8.0). B, C Standard uptake values (SUV, decay-corrected) for A375-hS100A4 (B) and MeWo tumors (C) with the respective muscle tissue as reference as a function of time (up to 1 h). Data shown are mean values of two mice each, which received a single injection of [¹⁸F]7b